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Anti-Desmin Antibody (8B607) (ready to use)

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Catalog No. TMAB-05096

Anti-Desmin Antibody (8B607) is a Mouse antibody targeting Desmin. Anti-Desmin Antibody (8B607) can be used in IHC-P,IHC-Fr,ICC/IF,IF.

Anti-Desmin Antibody (8B607) (ready to use)

Anti-Desmin Antibody (8B607) (ready to use)

😃Good
Catalog No. TMAB-05096
Anti-Desmin Antibody (8B607) is a Mouse antibody targeting Desmin. Anti-Desmin Antibody (8B607) can be used in IHC-P,IHC-Fr,ICC/IF,IF.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
3 mL$1047-10 days7-10 days
6 mL$1837-10 days7-10 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Anti-Desmin Antibody (8B607) is a Mouse antibody targeting Desmin. Anti-Desmin Antibody (8B607) can be used in IHC-P,IHC-Fr,ICC/IF,IF.
Ig Type
IgG1
Clone
8B607
Reactivity
Human
Application
Antibody Type
Monoclonal
Host SpeciesMouse
Subcellular LocalizationCytoplasm.
ConstructionHybridoma Monoclonal Antibody
PurificationProtein G purified
AppearanceLiquid
Formulation0.01M PBS (pH7.4) with 1% BSA and 0.02% Proclin300.
Research BackgroundDesmin is a muscle-specific, type III intermediate filament that integrates the sarcolemma, Z disk, and nuclear membrane in sarcomeres and regulates sarcomere architecture. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z line structures. Defects in Desmin are the cause of desmin related cardio skeletal myopathy (CSM) also known as desmin related myopathy (DRM). CSM is characterized by skeletal muscle weakness associated with cardiac conduction blocks, arrhythmias, restrictive heart failure, and by intracytoplasmic accumulation of desmin reactive deposits in cardiac and skeletal muscle cells. A desmin related myopathy can have a distal onset, it is then known as hereditary distal myopathy (HDM). Defects in Desmin are also the cause of dilated cardiomyopathy type 1I (CMD1I). CMD1I is an autosomal form of dilated cardiomyopathy characterized by ventricular dilatation and impaired systolic function. Antidesmin antibodies are useful in identification of tumours of myogenic origin
Antigen Details
Immunogen
KLH conjugated synthetic peptide: human Desmin
Antigen Species
Human
Gene Name
DES
Gene ID
Protein Name
Desmin
Uniprot ID
Function
Desmin are class-III intermediate filaments found in muscle cells. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures.
Chemical Properties
Molecular WeightTheoretical: 52 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 12 months, do not freeze.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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