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EBPC

Name: EBPC
Brand: TargetMol
SKU: T22757
Price: 36 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T22757Cas No. 4450-98-0

EBPC is an inhibitor of aldose reductase.

EBPC

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Purity: 99.55%

Catalog No. T22757Cas No. 4450-98-0

EBPC is an inhibitor of aldose reductase.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$36	In Stock	In Stock
5 mg	$74	In Stock	In Stock
10 mg	$113	In Stock	In Stock
25 mg	$203	In Stock	In Stock
50 mg	$291	In Stock	In Stock
100 mg	$413	In Stock	In Stock
200 mg	$557	-	In Stock
1 mL x 10 mM (in DMSO)	$83	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.55%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

EBPC AI Summary

EBPC exhibits potent inhibitory activity against various aldose and aldehyde reductases, including rat lens aldose reductase with IC50 values as low as 0.42 nM in the presence of D-glucose. The compound also inhibits pig kidney, whole kidney, and renal inner medulla aldehyde reductases with different IC50 values, demonstrating selectivity towards aldose reductases over aldehyde reductases with a selectivity ratio greater than 4000. Additionally, EBPC effectively reduces sorbitol accumulation in rat sciatic nerve and lens. Beyond its effects on reductases, EBPC is bioactive against diverse biological targets, including Menin-MLL interaction in leukemia, hydroxysteroid dehydrogenase, Jumonji Domain Containing 2E, Tau fibril formation, and multiple cytochrome enzymes. It also demonstrates inhibitory activity on HDAC6 enzyme with modest inhibition percentages in enzymatic assays..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

EBPC is an inhibitor of aldose reductase.

Chemical Properties

Molecular Weight	261.27
Formula	C₁₄H₁₅NO₄
Cas No.	4450-98-0
Smiles	CCOC(=O)C1=C(O)C(=O)N(CC2=CC=CC=C2)C1
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 65 mg/mL (248.78 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.8275 mL	19.1373 mL	38.2746 mL	191.3729 mL
5 mM	0.7655 mL	3.8275 mL	7.6549 mL	38.2746 mL
10 mM	0.3827 mL	1.9137 mL	3.8275 mL	19.1373 mL
20 mM	0.1914 mL	0.9569 mL	1.9137 mL	9.5686 mL
50 mM	0.0765 mL	0.3827 mL	0.7655 mL	3.8275 mL
100 mM	0.0383 mL	0.1914 mL	0.3827 mL	1.9137 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc