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Cephalexin hydrochloride

Name: Cephalexin hydrochloride
Brand: TargetMol
SKU: T22643
Price: 41 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: Cephacillin hydrochloride, Cefalexin hydrochloride) Copy Product Info

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Synonyms: Cephacillin hydrochloride, Cefalexin hydrochloride

Catalog No. T22643 Copy Product Info

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Cephalexin hydrochloride is a potent, orally active semisynthetic cephalosporin compound with a broad antibacterial spectrum. Cephalexin hydrochloride exhibits antibacterial activity against a wide range of gram-positive and gram-negative bacterial species. Cephalexin hydrochloride targets penicillin-binding proteins (PBPs) to inhibit bacterial cell wall assembly. Cephalexin hydrochloride is utilized in investigations involving pneumonia, streptococcal pharyngitis, bacterial endocarditis, and bacterial cell wall biosynthesis mechanisms.

Cas No. 59695-59-9

Pack Size	Price	USA Stock	Global Stock
10 mg	$29	-	In Stock
50 mg	Preferential	-	In Stock
1 mL x 10 mM (in DMSO)	$41	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Appearance:Solid

Color:Yellow

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COA

Product Introduction

Bioactivity

Description	Cephalexin hydrochloride is a potent, orally active semisynthetic cephalosporin compound with a broad antibacterial spectrum. Cephalexin hydrochloride exhibits antibacterial activity against a wide range of gram-positive and gram-negative bacterial species. Cephalexin hydrochloride targets penicillin-binding proteins (PBPs) to inhibit bacterial cell wall assembly. Cephalexin hydrochloride is utilized in investigations involving pneumonia, streptococcal pharyngitis, bacterial endocarditis, and bacterial cell wall biosynthesis mechanisms.
In vitro	Cephalexin hydrochloride (10μg/mL) disrupts polymer peptidoglycan (PG) biogenesis through the inactivation of enzymes known as penicillin-binding proteins (PBPs)[1]. Cephalexin hydrochloride exhibits inhibitory activity against a broad spectrum of Gram-positive and Gram-negative organisms, with MIC values of 2, 2, 2, 2, 4, 4.4, and 5.7 μg/mL for Bacillus anthracis, Edwardsiella tarda, Vibrio cholerae, Pasteurella multocida, Edwardsiella tarda, Alcaligenes sp., and Proteus rettgeri, respectively[2].
In vivo	Cephalexin hydrochloride (0-50 mg/kg; p.o.; 3.5 h) has antibacterial activity (Streptococcus pyogenes, Streptococcus pneumoniae, Staphylococcus aureus and several gram-negative) in male Swiss-Webster mice with infected bacterial[2].
Synonyms	Cephacillin hydrochloride, Cefalexin hydrochloride

Chemical Properties

Molecular Weight	383.85
Formula	C₁₆H₁₈ClN₃O₄S
Cas No.	59695-59-9
Smiles	O=C1N2[C@@]([C@@H]1NC([C@H](N)C3=CC=CC=C3)=O)(SCC(C)=C2C(O)=O)[H].Cl
Relative Density.	no data available

Storage & Solubility Information

Storage

Keep away from moisture, Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (208.41 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6052 mL	13.0259 mL	26.0518 mL	130.2592 mL
5 mM	0.5210 mL	2.6052 mL	5.2104 mL	26.0518 mL
10 mM	0.2605 mL	1.3026 mL	2.6052 mL	13.0259 mL
20 mM	0.1303 mL	0.6513 mL	1.3026 mL	6.5130 mL
50 mM	0.0521 mL	0.2605 mL	0.5210 mL	2.6052 mL
100 mM	0.0261 mL	0.1303 mL	0.2605 mL	1.3026 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Cephalexin Hydrochloride

Related Tags: Cephalexin hydrochloride chemical structure | Cephalexin hydrochloride in vivo | Cephalexin hydrochloride in vitro | Cephalexin hydrochloride formula | Cephalexin hydrochloride molecular weight