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Potassium oxonate

Name: Potassium oxonate
Brand: TargetMol
SKU: T5987
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5987Cas No. 2207-75-2

Alias Potassium otastat, Potassium azaorotate, Oxonic Acid (potassium salt)

Potassium oxonate is a uricase inhibitor that suppresses the phosphorylation of 5-FU to 5-fluorouridine-5'-monophosphate and is commonly used to establish hyperuricemia models.

Potassium oxonate

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Purity: 99.86%

Catalog No. T5987Alias Potassium otastat, Potassium azaorotate, Oxonic Acid (potassium salt)Cas No. 2207-75-2

Potassium oxonate is a uricase inhibitor that suppresses the phosphorylation of 5-FU to 5-fluorouridine-5'-monophosphate and is commonly used to establish hyperuricemia models.

Pack Size	Price	USA Warehouse	Global Warehouse
5 g	$31	-	In Stock
10 g	$48	-	In Stock
25 g	$106	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.86%

Appearance:Solid

Color:White

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COA LCMS

Product Introduction

Bioactivity

Description	Potassium oxonate is a uricase inhibitor that suppresses the phosphorylation of 5-FU to 5-fluorouridine-5'-monophosphate and is commonly used to establish hyperuricemia models.
In vivo	Potassium oxonate is a component of S-1, a mixture containing a prodrug of the antitumor agent 5-fluorouracil, that suppresses the gastrointestinal toxicity of 5-FU without inhibiting its antitumor activity in rats[1].Formulations containing Potassium oxonate have been used to treat gastric, pancreatic, lung, head, neck, and breast carcinomas[2].
Synonyms	Potassium otastat, Potassium azaorotate, Oxonic Acid (potassium salt)

Chemical Properties

Molecular Weight	195.17
Formula	C₄H₂KN₃O₄
Cas No.	2207-75-2
Smiles	[K+].[O-]C(=O)c1nc(=O)[nH]c(=O)[nH]1
Relative Density.	no data available

Storage & Solubility Information

Storage

store under nitrogen | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 9.09 mg/mL (46.57 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	5.1237 mL	25.6187 mL	51.2374 mL	256.1869 mL
5 mM	1.0247 mL	5.1237 mL	10.2475 mL	51.2374 mL
10 mM	0.5124 mL	2.5619 mL	5.1237 mL	25.6187 mL
20 mM	0.2562 mL	1.2809 mL	2.5619 mL	12.8093 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc