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Rhein
🥰Excellent
Catalog No. T2997Cas No. 478-43-3
Alias Rhubarb yellow, Rheinic Acid, Rheic Acid, NSC 38629, Monorhein
Rhein (NSC 38629) is an anthraquinone compound extracted from Polygonaceae Rheum Officinale with anti-inflammation and antitumor activities.
Rhein
🥰Excellent
Purity: 99.04%
Catalog No. T2997Alias Rhubarb yellow, Rheinic Acid, Rheic Acid, NSC 38629, MonorheinCas No. 478-43-3
Rhein (NSC 38629) is an anthraquinone compound extracted from Polygonaceae Rheum Officinale with anti-inflammation and antitumor activities.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 mg | $33 | In Stock | |
| 500 mg | $94 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $39 | In Stock |
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Purity:99.04%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Rhein (NSC 38629) is an anthraquinone compound extracted from Polygonaceae Rheum Officinale with anti-inflammation and antitumor activities. |
| In vitro | In diabetic nephropathy-afflicted db/db mice, Rhein effectively ameliorates diabetic renal lesions and mitigates hyperlipidemia by reducing plasma cholesterol (Chol), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), ApoE, and renal tissue transforming growth factor-β1 (TGF-β1). |
| In vivo | In chondrocytes, Rhein (35 µM) effectively inhibits the synthesis of IL-1β in human osteoarthritis synovium and exerts effects in cartilage by reducing the amount of IL-1R and inhibiting the production of NO induced by IL-1β. Additionally, Rhein is capable of inducing apoptosis in acute promyelocytic leukemia cells (HL-60). |
| Synonyms | Rhubarb yellow, Rheinic Acid, Rheic Acid, NSC 38629, Monorhein |
| Molecular Weight | 284.22 |
| Formula | C15H8O6 |
| Cas No. | 478-43-3 |
| Smiles | OC(=O)C1=CC2=C(C(O)=C1)C(=O)C1=C(C=CC=C1O)C2=O |
| Relative Density. | 1.3269 g/cm3 (Estimated) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 5.45 mg/mL (19.19 mM), Sonication is recommended.  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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