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Dibenzothiophene

Name: Dibenzothiophene
Brand: TargetMol
SKU: T0352
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0352Cas No. 132-65-0

Alias Imino semicarbazide, Diphenylene sulfide

Dibenzothiophene (Imino semicarbazide), a component of petroleum oils, is a sulfur-containing polycyclic aromatic hydrocarbon (PAH) derivate consisting of 3 fused rings with keratolytic activity.

Dibenzothiophene

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Purity: 99.82%

Catalog No. T0352Alias Imino semicarbazide, Diphenylene sulfideCas No. 132-65-0

Dibenzothiophene (Imino semicarbazide), a component of petroleum oils, is a sulfur-containing polycyclic aromatic hydrocarbon (PAH) derivate consisting of 3 fused rings with keratolytic activity.

Pack Size	Price	USA Warehouse	Global Warehouse
1 g	$31	-	In Stock
5 g	$50	-	In Stock
10 g	$59	-	In Stock
25 g	$75	-	In Stock
1 mL x 10 mM (in DMSO)	$29	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

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Purity:99.82%

Appearance:Solid

Color:White

Resource Download

COA HPLC HNMR

Product Introduction

Dibenzothiophene AI Summary

Dibenzothiophene exhibits a diverse range of bioactivities and inhibitory properties. It inhibits human CYP2C9, particularly in the context of (S)-Flurbiprofen hydroxylation, with an inhibition rate of -10.6%. The compound shows binding affinity to beta-cyclodextrin, displaying a log Ks value of 3.48. In cellular assays, it demonstrates significant inhibition of OATP1B3 and OATP1B1 transporters in CHO cells, with inhibition rates of 93.83% and 114.66% respectively at 10 µM. Moreover, Dibenzothiophene inhibits human BSEP activity, with an IC50 value of 387900.0 nM. In addition, the compound is noted for its antiviral properties. It inhibits SARS-CoV-2 induced cytotoxicity in VERO-6 and Caco-2 cells at 10 µM, with respective inhibition rates of 0.04% and -1.62% after 48 hours. Dibenzothiophene also shows a 12.6% inhibition of the SARS-CoV-2 3CL-Pro protease at 20 µM concentration, measured utilizing a FRET-based response assay. The compound exhibits bioactivity in several enzymatic assays, including inhibitors of USP1/UAF1, human tyrosyl-DNA phosphodiesterase 1 (TDP1), and possibly in assays targeting Ebola Virus entry. It also demonstrates an inhibitory effect on HDAC6 at 31.46% with a commercial peptide substrate, although inhibition slightly decreases to -0.85% with a custom peptide substrate. Dibenzothiophene shows potency in the nanomolar range and AC50 values in micromolar concentrations, underscoring its potential as a versatile bioactive compound..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Dibenzothiophene (Imino semicarbazide), a component of petroleum oils, is a sulfur-containing polycyclic aromatic hydrocarbon (PAH) derivate consisting of 3 fused rings with keratolytic activity.
In vivo	Dibenzothiophene, whose desulfurization removes monomeric sulfur, converts to 2-hydroxybiphenyl through a multi-enzyme pathway catalyzed by two monooxygenases and a desulfinase.
Synonyms	Imino semicarbazide, Diphenylene sulfide

Chemical Properties

Molecular Weight	184.26
Formula	C₁₂H₈S
Cas No.	132-65-0
Smiles	C1=2C=3C(SC1=CC=CC2)=CC=CC3
Relative Density.	1.252g/cm3

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 15 mg/mL (81.41 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: 1 mg/mL (5.43 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 1.5 mg/mL (8.14 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	5.4271 mL	27.1356 mL	54.2711 mL	271.3557 mL
5 mM	1.0854 mL	5.4271 mL	10.8542 mL	54.2711 mL

DMSO

	1mg	5mg	10mg	50mg
10 mM	0.5427 mL	2.7136 mL	5.4271 mL	27.1356 mL
20 mM	0.2714 mL	1.3568 mL	2.7136 mL	13.5678 mL
50 mM	0.1085 mL	0.5427 mL	1.0854 mL	5.4271 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc