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Anti-Lipocalin-2/LCN2 Antibody (5H677)

😃Good
Catalog No. TMAH-00684
Alias Siderocalin LCN2, p25, Oncogene 24p3, NGAL, MSFI, Lipocalin-2

Anti-Lipocalin-2/LCN2 Antibody (5H677) is a Mouse antibody targeting Lipocalin-2/LCN2. Anti-Lipocalin-2/LCN2 Antibody (5H677) can be used in ELISA, WB, IHC.

Anti-Lipocalin-2/LCN2 Antibody (5H677)

Anti-Lipocalin-2/LCN2 Antibody (5H677)

😃Good
Catalog No. TMAH-00684Alias Siderocalin LCN2, p25, Oncogene 24p3, NGAL, MSFI, Lipocalin-2
Anti-Lipocalin-2/LCN2 Antibody (5H677) is a Mouse antibody targeting Lipocalin-2/LCN2. Anti-Lipocalin-2/LCN2 Antibody (5H677) can be used in ELISA, WB, IHC.
Pack SizePriceAvailabilityQuantity
50 μg$207 7-10 days
100 μg$349 7-10 days
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Product Introduction

Bioactivity
Description
Antibody Type: Mouse Monoclonal

Application: ELISA, WB, IHC

Reactivity: Human, Mouse
AliasSiderocalin LCN2, p25, Oncogene 24p3, NGAL, MSFI, Lipocalin-2
Ig Type
IgG2b
Clone
5H677
Reactivity
Human, Mouse
Verified Activity
1. Western Blot
-All lanes:Mouse anti-human Neutrophil gelatinase-associated lipocalin monoclonal antibody at 1μg/ml
-Lane 1:NGAL transfected 293 cell lysate
-Predicted band size : 22 kDa
-Observed band size : 25 kDa
2. Immunohistochemical of paraffin-embedded human spleen organization using TMAH-00684 at dilution of 1:200
3. Immunohistochemical of paraffin-embedded human prostate tissue using TMAH-00684 at dilution of 1:200
Application
ELISA, WB, IHC
Antibody Type
Monoclonal
Host SpeciesMouse
Subcellular LocalizationSecreted. Cytoplasmic granule lumen. Cytoplasmic vesicle lumen.
ConstructionHybridoma Monoclonal Antibody
PurificationProtein G purified
AppearanceLiquid
FormulationPreservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4.
Purity>95%
Research BackgroundIron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,3-dihydroxybenzoic acid (2,3-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity; limits bacterial proliferation by sequestering iron bound to microbial siderophores, such as enterobactin. Can also bind siderophores from M.tuberculosis.
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Immunogen
Recombinant Protein: Human Neutrophil gelatinase-associated lipocalin Protein
Antigen Species
Human
Gene ID
3934
Uniprot ID
Biology Area
Immunology
Chemical Properties
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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