Anti-Insulin Receptor Antibody-PE (6Y412)

Name: Anti-Insulin Receptor Antibody-PE (6Y412)
Brand: TargetMol
SKU: TMAY-01626P
Rating: 4.5 (1 reviews)

(Synonyms: Insulin Receptor, HHF5, CD220) Copy Product Info

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Synonyms: Insulin Receptor, HHF5, CD220

Catalog No. TMAY-01626P Copy Product Info

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Anti-Insulin Receptor Antibody-PE (6Y412) is a PE-conjugated Mouse antibody targeting Insulin Receptor. Anti-Insulin Receptor Antibody-PE (6Y412) can be used in FCM.

Pack Size	Price	USA Stock	Global Stock	Quantity
25 T	$82	7-10 days	7-10 days
100 T	$174	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Bioactivity

Description	Anti-Insulin Receptor Antibody-PE (6Y412) is a PE-conjugated Mouse antibody targeting Insulin Receptor. Anti-Insulin Receptor Antibody-PE (6Y412) can be used in FCM.
Synonyms	Insulin Receptor, HHF5, CD220
Ig Type	Mouse IgG1
Clone	6Y412
Reactivity	Human
Specificity	Human Insulin Receptor

Application	FCM
Recommended Dose	10 μl/Test, 0.1 mg/ml
Antibody Type	Monoclonal
Host Species	Mouse
Construction	This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Insulin Receptor/INSR/CD220 (rh Insulin Receptor/INSR/CD220; TMPY-01149; NP_001073285.1; Met1-Lys944) and conjugated with PE under optimum conditions, the unreacted PE was removed.
Purification	Protein A
Appearance	Liquid
Formulation	PBS solution containing 0.5% BSA and 0.03%ProClin300
Research Background	INSR (Insulin receptor), also known as CD220, is a transmembrane receptor that is activated by insulin. INSR belongs to the protein kinase superfamily and exists as a tetramer consisting of two alpha subunits and two beta subunits linked by disulfide bonds. The alpha and beta subunits are encoded by a single INSR gene, and the beta subunits pass through the cellular membrane. As the receptor for insulin with tyrosine-protein kinase activity, INSR associates with downstream mediators upon binding to insulin, including IRS1 (insulin receptor substrate 1) and phosphatidylinositol 3'-kinase (PI3K). IRS-1 binding and phosphorylation eventually lead to an increase in the high-affinity glucose transporter (Glut4) molecules on the outer membrane of insulin-responsive tissues. INSR isoform long and isoform short are expressed in the peripheral nerve, kidney, liver, striated muscle, fibroblasts and skin, and is found as a hybrid receptor with IGF1R which also binds IGF1 in muscle, heart, kidney, adipose tissue, skeletal muscle, hepatoma, fibroblasts, spleen, and placenta. Defects in Insulin Receptor/INSR are the cause of Rabson-Mendenhall syndrome (Mendenhall syndrome), insulin resistance (Ins resistance), leprechaunism (Donohue syndrome), and familial hyperinsulinemic hypoglycemia 5 (HHF5). It may also be associated with noninsulin-dependent diabetes mellitus (NIDDM).