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Anti-Insulin Receptor Antibody-PE (6Y412)
🥰Excellent
Catalog No. TMAY-01626P
Anti-Insulin Receptor Antibody-PE (6Y412) is a PE-conjugated Mouse antibody targeting Insulin Receptor. Anti-Insulin Receptor Antibody-PE (6Y412) can be used in FCM.
Anti-Insulin Receptor Antibody-PE (6Y412)
Anti-Insulin Receptor Antibody-PE (6Y412)
🥰Excellent
Catalog No. TMAY-01626P
Anti-Insulin Receptor Antibody-PE (6Y412) is a PE-conjugated Mouse antibody targeting Insulin Receptor. Anti-Insulin Receptor Antibody-PE (6Y412) can be used in FCM.
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Product Introduction
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Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-Insulin Receptor Antibody-PE (6Y412) is a PE-conjugated Mouse antibody targeting Insulin Receptor. Anti-Insulin Receptor Antibody-PE (6Y412) can be used in FCM. |
| Ig Type | Monoclonal Mouse IgG1 |
| Clone | 6Y412 |
| Reactivity | Human |
| Verified Activity | Flow cytometric analysis of Human INSR(CD220) expression on human whole blood monocytes. Cells were stained with PE-conjugated anti-Human INSR(CD220). The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of viable monocytes. |
| Application | FCM |
| Recommended Dose | 10 μl/Test, 0.1 mg/ml |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Insulin Receptor/INSR/CD220 (rh Insulin Receptor/INSR/CD220; TMPY-01149; NP_001073285.1; Met1-Lys944) and conjugated with PE under optimum conditions, the unreacted PE was removed. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | PBS solution containing 0.5% BSA and 0.03%ProClin300 |
| Research Background | INSR (Insulin receptor), also known as CD220, is a transmembrane receptor that is activated by insulin. INSR belongs to the protein kinase superfamily and exists as a tetramer consisting of two alpha subunits and two beta subunits linked by disulfide bonds. The alpha and beta subunits are encoded by a single INSR gene, and the beta subunits pass through the cellular membrane. As the receptor for insulin with tyrosine-protein kinase activity, INSR associates with downstream mediators upon binding to insulin, including IRS1 (insulin receptor substrate 1) and phosphatidylinositol 3'-kinase (PI3K). IRS-1 binding and phosphorylation eventually lead to an increase in the high-affinity glucose transporter (Glut4) molecules on the outer membrane of insulin-responsive tissues. INSR isoform long and isoform short are expressed in the peripheral nerve, kidney, liver, striated muscle, fibroblasts and skin, and is found as a hybrid receptor with IGF1R which also binds IGF1 in muscle, heart, kidney, adipose tissue, skeletal muscle, hepatoma, fibroblasts, spleen, and placenta. Defects in Insulin Receptor/INSR are the cause of Rabson-Mendenhall syndrome (Mendenhall syndrome), insulin resistance (Ins resistance), leprechaunism (Donohue syndrome), and familial hyperinsulinemic hypoglycemia 5 (HHF5). It may also be associated with noninsulin-dependent diabetes mellitus (NIDDM). |
| Conjucates | PE |
| Others Formats | Unconjugated |
| Antibody Types Available | 2 |
| Immunogen | Recombinant Human Insulin Receptor/INSR/CD220 Protein (TMPY-01149) |
| Antigen Species | Human |
| Biology Area | Receptor Tyrosine Kinases (RTKs) |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. |
| Transport | Shipping with blue ice. |
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