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ARN2966

🥰Excellent
Catalog No. T7490Cas No. 102212-26-0

ARN2966 is an inhibitor of amyloid precursor protein (APP)and amyloid-β (Aβ) secretion.

ARN2966

ARN2966

🥰Excellent
Purity: 99.86%
Catalog No. T7490Cas No. 102212-26-0
ARN2966 is an inhibitor of amyloid precursor protein (APP)and amyloid-β (Aβ) secretion.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$31In StockIn Stock
5 mg$72In StockIn Stock
10 mg$122In StockIn Stock
25 mg$247In StockIn Stock
50 mg$397In StockIn Stock
100 mg$589In StockIn Stock
500 mg$1,280-In Stock
1 mL x 10 mM (in DMSO)$79In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information

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Purity:99.86%
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COA HNMR LCMS

Product Introduction

Bioactivity
Description
ARN2966 is an inhibitor of amyloid precursor protein (APP)and amyloid-β (Aβ) secretion.
In vitro
ARN2966 reduces levels of APP and its intracellular C-terminal fragments α-CTF and β-CTF in CHO APP751SW cells when used at a concentration of 10 μM. ARN2966?also reduces?secretion of Aβ (1-40) and Aβ (1-42) by 88.6 and 84.9%, respectively.
In vivo
In vivo,ARN2966? reduces brain levels of full-length APP, α-CTF and β-CTF, and soluble Aβ (1-40) and Aβ (1-42) in the APPSWPS1dE9 transgenic mouse model of Alzheimer's disease.?It also improves novel object memory as well as spatial memory in the radial arm maze in APPSWPS1dE9 transgenic mice.
Chemical Properties
Molecular Weight200.24
FormulaC12H12N2O
Cas No.102212-26-0
SmilesOc1ccccc1NCc1ccccn1
Relative Density.1.241 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 55 mg/mL (274.67 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (9.99 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM4.9940 mL24.9700 mL49.9401 mL249.7004 mL
5 mM0.9988 mL4.9940 mL9.9880 mL49.9401 mL
10 mM0.4994 mL2.4970 mL4.9940 mL24.9700 mL
20 mM0.2497 mL1.2485 mL2.4970 mL12.4850 mL
50 mM0.0999 mL0.4994 mL0.9988 mL4.9940 mL
100 mM0.0499 mL0.2497 mL0.4994 mL2.4970 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

β-amyloid peptideβAmyloidβ AmyloidInhibitorinhibitBetaAmyloidBeta AmyloidbAmyloidb AmyloidARN-2966ARN2966ARN 2966amyloid-βAmyloid-βAbeta
Related Tags: buy ARN2966 | purchase ARN2966 | ARN2966 cost | order ARN2966 | ARN2966 chemical structure | ARN2966 in vivo | ARN2966 in vitro | ARN2966 formula | ARN2966 molecular weight
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