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3-Methoxybenzamide

Name: 3-Methoxybenzamide
Brand: TargetMol
SKU: T7439
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7439Cas No. 5813-86-5

Alias 3-MBA

3-Methoxybenzamide (3-MBA) is a competitive inhibitor of poly(ADP-ribose) synthetase.

3-Methoxybenzamide

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Purity: 98.52%

Catalog No. T7439Alias 3-MBACas No. 5813-86-5

3-Methoxybenzamide (3-MBA) is a competitive inhibitor of poly(ADP-ribose) synthetase.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$35	In Stock	In Stock
50 mg	$56	In Stock	In Stock
100 mg	$81	In Stock	In Stock
500 mg	$208	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:98.52%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

3-Methoxybenzamide AI Summary

3-Methoxybenzamide exhibits multifaceted bioactivity, including the inhibition of poly(ADP-ribose)-polymerase (PARP) with IC50 values of 17000 nM and 30000 nM reported from different sources. Additionally, it shows significant antibacterial activity against various bacterial strains. In Staphylococcus aureus ATCC 29213, it has Minimum Inhibitory Concentration (MIC) values of 2048 µg/mL under standard conditions and 4096 µg/mL in the presence of 2% bovine serum albumin. Against Bacillus subtilis, especially FtsZ mutants, the compound demonstrates higher MIC values compared to wild-type strains. It effectively inhibits FtsZ-mediated cell division in Bacillus subtilis 168 at 500 µg/mL. For Staphylococcus epidermidis ATCC 12228, the MIC value is 4096 µg/mL. Furthermore, 3-Methoxybenzamide has demonstrated bioactivity as an inhibitor in TGF-β and USP1/UAF1 assays with a potency of 31622.8 nM. The broad-spectrum antibacterial activity encompasses penicillin-susceptible and methicillin-resistant strains of Staphylococcus aureus, penicillin-susceptible Streptococcus pyogenes, and Streptococcus pneumoniae, with MIC values ranging from >128 µg/mL to 4096 µg/mL. It also inhibits cell division in Bacillus subtilis at 512 µg/mL, as evident from phase-contrast light microscopy analyses..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	3-Methoxybenzamide (3-MBA) is a competitive inhibitor of poly(ADP-ribose) synthetase.
Synonyms	3-MBA

Chemical Properties

Molecular Weight	151.16
Formula	C₈H₉NO₂
Cas No.	5813-86-5
Smiles	COC1=CC=CC(=C1)C(N)=O
Relative Density.	1.143g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (363.85 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	6.6155 mL	33.0775 mL	66.1551 mL	330.7753 mL
5 mM	1.3231 mL	6.6155 mL	13.2310 mL	66.1551 mL
10 mM	0.6616 mL	3.3078 mL	6.6155 mL	33.0775 mL
20 mM	0.3308 mL	1.6539 mL	3.3078 mL	16.5388 mL
50 mM	0.1323 mL	0.6616 mL	1.3231 mL	6.6155 mL
100 mM	0.0662 mL	0.3308 mL	0.6616 mL	3.3078 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc