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Cefotaxime

Name: Cefotaxime
Brand: TargetMol
SKU: T7733
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7733Cas No. 63527-52-6

Cefotaxime is an inhibitor of penicillin binding protein.

Cefotaxime

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Purity: 99.77%

Catalog No. T7733Cas No. 63527-52-6

Cefotaxime is an inhibitor of penicillin binding protein.

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$30	In Stock	In Stock
100 mg	$40	In Stock	In Stock
500 mg	$108	In Stock	In Stock
1 g	$162	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$44	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.77%

Color:Yellow

Resource Download

COA HNMR HPLC

Product Introduction

Cefotaxime AI Summary

Cefotaxime exhibits broad-spectrum antibacterial activity against a variety of bacterial pathogens, including Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Streptococcus pyogenes, with notable low minimum inhibitory concentrations (MIC) indicative of its potent antibacterial efficacy. Specific MIC values include 0.06 ug/mL against Klebsiella pneumoniae and 0.03 ug/mL against Escherichia coli strains, highlighting its broad applicability. Additionally, the compound shows inhibitory effects on penicillin-binding proteins (PBPs) and various beta-lactamases, enhancing its effectiveness against resistant bacterial strains. In vivo murine models evidenced its therapeutic potential at effective doses (ED50) for infectious treatments. While demonstrating strong in vitro and in vivo results, Cefotaxime exhibits differential activity with reduced effectiveness against multi-resistant strains such as certain Pseudomonas aeruginosa and Staphylococcus aureus strains. Documented pharmacokinetic properties indicate a short half-life and high clearance rate, necessitating considerations in dosing regimens for clinical applications..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Cefotaxime is an inhibitor of penicillin binding protein.

Chemical Properties

Molecular Weight	455.47
Formula	C₁₆H₁₇N₅O₇S₂
Cas No.	63527-52-6
Smiles	C(O)(=O)C=1N2[C@@]([C@H](NC(/C(=N\OC)/C=3N=C(N)SC3)=O)C2=O)(SCC1COC(C)=O)[H]
Relative Density.	1.8 g/cm3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 255 mg/mL (559.86 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (7.25 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1955 mL	10.9777 mL	21.9553 mL	109.7767 mL
5 mM	0.4391 mL	2.1955 mL	4.3911 mL	21.9553 mL
10 mM	0.2196 mL	1.0978 mL	2.1955 mL	10.9777 mL
20 mM	0.1098 mL	0.5489 mL	1.0978 mL	5.4888 mL
50 mM	0.0439 mL	0.2196 mL	0.4391 mL	2.1955 mL
100 mM	0.0220 mL	0.1098 mL	0.2196 mL	1.0978 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc