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Parsaclisib hydrochloride (Alias: Parsaclisib HCl, INCB50465 HCl, INCB-50465, INCB050465 HCl, INCB-050465...)

Name: Parsaclisib hydrochloride
Brand: TargetMol
SKU: T28297
Rating: 4.5 (1 reviews)

Catalog No. T28297 Copy Product Info

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Parsaclisib hydrochloride (INCB050465 HCl) is a selectve PI3Kδ inhibitor with antitumor activity. Parsaclisib demonstrates potent activity with IC50 values ranging from 0.2 to 2 nM.

Parsaclisib hydrochloride

Copy Product Info

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Catalog No. T28297

Alias Parsaclisib HCl, INCB50465 HCl, INCB-50465, INCB050465 HCl, INCB-050465, INCB 50465, INCB 050465

Parsaclisib hydrochloride (INCB050465 HCl) is a selectve PI3Kδ inhibitor with antitumor activity. Parsaclisib demonstrates potent activity with IC50 values ranging from 0.2 to 2 nM.

Cas No. 1995889-48-9

Pack Size	Price	USA Stock	Global Stock
25 mg	$1,230	1-2 weeks	1-2 weeks
50 mg	$1,610	1-2 weeks	1-2 weeks
100 mg	$2,570	1-2 weeks	1-2 weeks

In stock · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Introduction

Bioactivity

Description	Parsaclisib hydrochloride (INCB050465 HCl) is a selectve PI3Kδ inhibitor with antitumor activity. Parsaclisib demonstrates potent activity with IC50 values ranging from 0.2 to 2 nM.
Targets&IC50	PI3Kδ:1 nM (IC50)
Synonyms	Parsaclisib HCl, INCB50465 HCl, INCB-50465, INCB050465 HCl, INCB-050465, INCB 50465, INCB 050465

Chemical Properties

Molecular Weight	469.34
Formula	C₂₀H₂₃Cl₂FN₆O₂
Cas No.	1995889-48-9
Smiles	Cl.CCOc1c(cc(Cl)c(F)c1[C@@H]1CNC(=O)C1)[C@H](C)n1nc(C)c2c(N)ncnc12
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (191.76 mM), Sonication is recommended.

H2O: Insoluble

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1307 mL	10.6533 mL	21.3065 mL	106.5326 mL
5 mM	0.4261 mL	2.1307 mL	4.2613 mL	21.3065 mL
10 mM	0.2131 mL	1.0653 mL	2.1307 mL	10.6533 mL
20 mM	0.1065 mL	0.5327 mL	1.0653 mL	5.3266 mL
50 mM	0.0426 mL	0.2131 mL	0.4261 mL	2.1307 mL
100 mM	0.0213 mL	0.1065 mL	0.2131 mL	1.0653 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc