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Anti-GPRC5D Antibody-PE (2N672) is a PE-conjugated Mouse antibody targeting GPRC5D. Anti-GPRC5D Antibody-PE (2N672) can be used in FCM.
Description | Anti-GPRC5D Antibody-PE (2N672) is a PE-conjugated Mouse antibody targeting GPRC5D. Anti-GPRC5D Antibody-PE (2N672) can be used in FCM. |
Ig Type | Monoclonal Mouse IgG2b |
Clone | 2N672 |
Reactivity | Human |
Verified Activity | Flow cytometric analysis of Human GPRC5D expression on CHO-K1 Cells were stained with PE-conjugated anti-Human GPRC5D. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
Application | FCM |
Recommended Dose | 5 μL/Test, 0.1 mg/mL |
Antibody Type | Monoclonal |
Host Species | Mouse |
Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human GPRC5D. The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography, and conjugated with PE under optimum conditions, the unreacted PE was removed. |
Purification | Protein A |
Appearance | Liquid |
Formulation | PBS solution containing 0.5% BSA and 0.03%ProClin300 |
Research Background | Orphan G-protein-coupled receptor family C group 5 member D (GPRC5D) has seven transmembrane segments forming the core of the receptor, as well as an intracellular C-tail and an extracellular N-terminal domain. GPRC5D is highly and selectively expressed on the surface of CD138+ multiple myeloma (MM) cells, whereas in normal tissues, a much lower expression is limited to plasma cells and certain hard keratinizing tissues. This makes GPRC5D a promising marker for monitoring tumor load and a target antigen for MM-specific T cell-engaging therapies such as bispecific antibodies and CAR-T cells. |
Conjucates | PE |
Others Formats | Unconjugated/APC/FITC |
Antibody Types Available | 4 |
Immunogen | Recombinant Human GPRC5D Protein |
Antigen Species | Human |
Stability & Storage | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. |
Transport | Shipping with blue ice. |
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