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2-Ethoxybenzamide

Name: 2-Ethoxybenzamide
Brand: TargetMol
SKU: T0058
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0058Cas No. 938-73-8

Alias Ethenzamide, Anovigam

2-Ethoxybenzamide (Anovigam) is white or almost-white crystalline powder. Almost odorless. Tasteless. It is widely used as an antipyretic anodyne.

2-Ethoxybenzamide

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Purity: 99.75%

Catalog No. T0058Alias Ethenzamide, AnovigamCas No. 938-73-8

2-Ethoxybenzamide (Anovigam) is white or almost-white crystalline powder. Almost odorless. Tasteless. It is widely used as an antipyretic anodyne.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 g	$29	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.75%

Appearance:Solid

Color:White

Resource Download

COA LCMS HPLC HNMR

Product Introduction

2-Ethoxybenzamide AI Summary

2-Ethoxybenzamide exhibits a range of bioactivities, demonstrating its potential in multiple biological contexts. It shows potency in inhibiting anthrax lethal toxin internalization and acts as an antagonist of androgen receptor signaling. Additionally, it demonstrates agonistic activity towards thyroid hormone receptor beta signaling and displays inhibitory effects on TDP-43. It is effective in blocking the entry of Ebola virus, albeit with varying potencies across different screening channels. In antiviral studies, 2-Ethoxybenzamide shows low bioactivity in inhibiting cell viability in Vero E6 cells infected with SARS-CoV-2 (strain BavPat1). It inhibits SARS-CoV-2-induced cytotoxicity in Caco-2 cells with an inhibition rate of -27.23% at 10 μM concentration after 48 hours. Similarly, it demonstrates antiviral activity in HRCE cells against the SARS-CoV-2 (USA-WA1/2020 strain), with a hit score of 0.115. It also displays varying degrees of inhibitory effects against SARS-CoV-2-induced cytotoxicity in VERO-6 cells, with inhibitory percentages ranging from 0.02% to 0.05% at 10 μM after 48 hours. The IC50 for its antiviral activity is greater than 20,000 nM. Moreover, 2-Ethoxybenzamide exhibits inhibitory activity against the human HDAC6 enzyme, showing 18.68% inhibition using a commercial peptide substrate and 5.47% inhibition using a custom peptide substrate. However, it does not show significant binding affinity or inhibition towards tested receptors and enzymes at higher concentrations (AC50 > 30,000 nM), nor does it demonstrate significant agonistic or antagonistic activities in cell-based assays. Finally, the compound has a low in-vivo plasma to lung partition coefficient in rats, with a logP(lung) value of -0.03, suggesting it may preferentially distribute from the plasma into the lung tissue. Overall, 2-Ethoxybenzamide exhibits multiple bioactivities, indicating a broad spectrum of biological potential, although with variable efficacy across different targets and assays..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	2-Ethoxybenzamide (Anovigam) is white or almost-white crystalline powder. Almost odorless. Tasteless. It is widely used as an antipyretic anodyne.
Synonyms	Ethenzamide, Anovigam

Chemical Properties

Molecular Weight	165.19
Formula	C₉H₁₁NO₂
Cas No.	938-73-8
Smiles	CCOC1=CC=CC=C1C(N)=O
Relative Density.	1.111 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 65 mg/mL (393.49 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	6.0536 mL	30.2682 mL	60.5364 mL	302.6818 mL
5 mM	1.2107 mL	6.0536 mL	12.1073 mL	60.5364 mL
10 mM	0.6054 mL	3.0268 mL	6.0536 mL	30.2682 mL
20 mM	0.3027 mL	1.5134 mL	3.0268 mL	15.1341 mL
50 mM	0.1211 mL	0.6054 mL	1.2107 mL	6.0536 mL
100 mM	0.0605 mL	0.3027 mL	0.6054 mL	3.0268 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc