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Anti-GNS Antibody (8J37)
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Catalog No. TMAY-00606
Alias N-Acetylglucosamine-6-Sulfatase, GNS, Glucosamine-6-Sulfatase, G6S
Anti-GNS Antibody (8J37) is a Rabbit antibody targeting GNS. Anti-GNS Antibody (8J37) can be used in WB,ELISA.
Anti-GNS Antibody (8J37)
Anti-GNS Antibody (8J37)
😃Good
Catalog No. TMAY-00606Alias N-Acetylglucosamine-6-Sulfatase, GNS, Glucosamine-6-Sulfatase, G6S
Anti-GNS Antibody (8J37) is a Rabbit antibody targeting GNS. Anti-GNS Antibody (8J37) can be used in WB,ELISA.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $269 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-GNS Antibody (8J37) is a Rabbit antibody targeting GNS. Anti-GNS Antibody (8J37) can be used in WB,ELISA. |
| Alias | N-Acetylglucosamine-6-Sulfatase, GNS, Glucosamine-6-Sulfatase, G6S |
| Ig Type | Monoclonal Rabbit IgG |
| Clone | 8J37 |
| Reactivity | Human |
| Verified Activity | Anti-GNS rabbit monoclonal antibody at 1:500 dilution. -Lane A: PC3 Whole Cell lysate. -Lysates/proteins at 30 μg per lane. -Secondary -Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution. -Developed using the Odyssey technique. -Performed under reducing conditions. -Predicted band size:62 kDa. -Observed band size:95 kDa |
| Application | WB,ELISA |
| Recommended Dose | WB: 1:500-1:2000; ELISA: 1:5000-1:10000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Human GNS / G6S (rhGNS; NP_002067.1Met 1-Leu 552). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Glucosamine (N-acetyl)-6-sulfatase (GNS), also known as G6S, a hydrolase, which is one of the enzymes involved in heparan sulfate catabolism leading to lysosomal storage. GNS is required for the catabolism of the glycosaminoglycans (GAG) including heparin, heparan sulfate, and keratan sulfate through the hydrolysis of the 6-sulfate group from the N-acetyl-D-glucosamine 6-sulfate units. Mucopolysaccharidosis type IIID (MPS IIID) is the least common of the four subtypes of Sanfilippo syndrome. It is caused by a deficiency of N-acetylglucosamine-6-sulphatase. A mutation in GNS resulting in MPS IIID indicates the potential utility of molecular diagnosis for this rare condition. As the least common type of the four subtypes of Sanfilippo syndrome, MPS IIID has profound mental deterioration, hyperactivity, and relatively mild somatic manifestations. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Human GNS protein |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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