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Anti-ARSA Antibody (6H122)
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Catalog No. TMAY-00844
Alias TISP73, AW212749, AS-A, ASA, As-2, As2, arylsulfatase A
Anti-ARSA Antibody (6H122) is a Rabbit antibody targeting ARSA. Anti-ARSA Antibody (6H122) can be used in WB.
Anti-ARSA Antibody (6H122)
Anti-ARSA Antibody (6H122)
😃Good
Catalog No. TMAY-00844Alias TISP73, AW212749, AS-A, ASA, As-2, As2, arylsulfatase A
Anti-ARSA Antibody (6H122) is a Rabbit antibody targeting ARSA. Anti-ARSA Antibody (6H122) can be used in WB.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $270 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Rabbit Monoclonal Application: WB Reactivity: Human |
| Alias | TISP73, AW212749, AS-A, ASA, As-2, As2, arylsulfatase A |
| Ig Type | Rabbit IgG |
| Clone | 6H122 |
| Reactivity | Human |
| Verified Activity | Anti-ARSA rabbit monoclonal antibody at 1:500 dilution. -Lane A: HepG2 Whole Cell lysate. -Lysates/proteins at 30 μg per lane. -Secondary -Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution. -Developed using the Odyssey technique. -Performed under reducing conditions. -Predicted band size:54 kDa. -Observed band size:60 kDa |
| Application | WB |
| Recommended Dose | WB: 1:500-1:2000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Human Arylsulfatase A / ARSA (rh Arylsulfatase A / ARSA; TMPY-00669; P15289-1; Met 1-Ala 507). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Arylsulfatase A (ARSA) is synthesized as a 52KDa lysosomal enzyme. It is a member of the sulfatase family that is required for the lysosomal degradation of cerebroside-3-sulfate, a sphingolipid sulfate ester and a major constituent of the myelin sheet. Arylsulfatase A is activated by a required co- or posttranslational modification with the oxidation of cysteine to formylglycine. Metachromatic leukodystrophy (MLD) is a lysosomal storage disease in the central and peripheral nervous systems with severe and progressive neurological symptoms caused by the deficiency of Arylsulfatase A. Deficiency of this enzyme is also found in apparently healthy individuals, a condition for which the term pseudodeficiency is introduced. ARSA forms dimers after receiving three N-linked oligosaccharides in the endoplasmic reticulum, and then the dimers are transported to the Golgi where they receive mannose 6-phosphate recognition markers. And thus, ARSA is transported and delivered to dense lysosomes in a mannose 6-phosphate receptor-dependent manner. It has been shown that within the lysosomes, the ARSA dimers can oligomerize to an octamer in a pH-dependent manner. The ARSA deficiency leads to metachromatic leucodystrophy (MLD), a lysosomal storage disorder associated with severe and progressive demyelination in he central and peripheral nervous system. Additionally, the serum level of arylsulfatase A might be helpful in diagnosis of lung and central nervous system cancer. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human Arylsulfatase A / ARSA protein (TMPY-00669) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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