Shopping Cart

Remove All
Your shopping cart is currently empty

PF-AKT400

Name: PF-AKT400
Brand: TargetMol
SKU: T5508
Price: 96 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T5508Cas No. 1004990-28-6

Alias AKT protein kinase inhibitor

PF-AKT400 (AKT protein kinase inhibitor) is a broadly selective and ATP-competitive inhibitor of Akt.

PF-AKT400

🥰Excellent

Purity: 98.21%

Catalog No. T5508Alias AKT protein kinase inhibitorCas No. 1004990-28-6

PF-AKT400 (AKT protein kinase inhibitor) is a broadly selective and ATP-competitive inhibitor of Akt.

Pack Size	Price	Availability
1 mg	$96	In Stock
5 mg	$239	In Stock
10 mg	$343	In Stock
25 mg	$579	In Stock
50 mg	$829	In Stock
100 mg	$1,150	In Stock
1 mL x 10 mM (in DMSO)	$263	In Stock

Add to Cart

Add to Quotation

Bulk & Custom

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:98.21%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	PF-AKT400 (AKT protein kinase inhibitor) is a broadly selective and ATP-competitive inhibitor of Akt.
Targets&IC50	PKA:450 nM , PKBα:0.5 nM
Synonyms	AKT protein kinase inhibitor

Chemical Properties

Molecular Weight	400.43
Formula	C₂₀H₂₂F₂N₆O
Cas No.	1004990-28-6
Smiles	CCc1c[nH]c2ncnc(N3CC[C@](N)(CNC(=O)c4ccc(F)cc4F)C3)c12
Relative Density.	1.353 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (224.76 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4973 mL	12.4866 mL	24.9732 mL	124.8658 mL
5 mM	0.4995 mL	2.4973 mL	4.9946 mL	24.9732 mL
10 mM	0.2497 mL	1.2487 mL	2.4973 mL	12.4866 mL
20 mM	0.1249 mL	0.6243 mL	1.2487 mL	6.2433 mL
50 mM	0.0499 mL	0.2497 mL	0.4995 mL	2.4973 mL
100 mM	0.0250 mL	0.1249 mL	0.2497 mL	1.2487 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc