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IWP-4
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Catalog No. T4245Cas No. 686772-17-8
Alias Inhibitor of Wnt Production-4
IWP-4 (Inhibitor of Wnt Production-4) is a potent Wnt inhibitor.
IWP-4
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Purity: 99.59%
Catalog No. T4245Alias Inhibitor of Wnt Production-4Cas No. 686772-17-8
IWP-4 (Inhibitor of Wnt Production-4) is a potent Wnt inhibitor.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $42 | In Stock | In Stock | |
| 5 mg | $93 | In Stock | In Stock | |
| 10 mg | $147 | In Stock | In Stock | |
| 25 mg | $347 | In Stock | In Stock | |
| 50 mg | $518 | In Stock | In Stock | |
| 100 mg | $749 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.59%
Appearance:Solid
Color:White to Yellow
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Product Introduction
IWP-4 AI Summary
IWP-4 inhibits porcupine-mediated Wnt signaling in mouse L cells after 24 hours, as evidenced by the SpringerImages-Topflash reporter assay with an EC50 of 25.0 nM. Additionally, it serves as an inhibitor of CK1delta and CK1epsilon kinases, showing varying levels of activity and IC50 values against different substrates and mutants. The compound also exhibits antiproliferative activity against a variety of human cell lines, with EC50 values ranging from 230.0 nM to 930.0 nM after 48 hours, suggesting potential cytotoxic effects. Furthermore, IWP-4 demonstrates selectivity in inhibiting human CK1epsilon over rat recombinant CK1delta kinase domain, with selectivity ratios indicating higher potency against the human enzyme in specific assays..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | IWP-4 (Inhibitor of Wnt Production-4) is a potent Wnt inhibitor. |
| Targets&IC50 | Wnt:25 nM. |
| Synonyms | Inhibitor of Wnt Production-4 |
| Molecular Weight | 496.62 |
| Formula | C23H20N4O3S3 |
| Cas No. | 686772-17-8 |
| Smiles | COc1ccccc1-n1c(SCC(=O)Nc2nc3ccc(C)cc3s2)nc2CCSc2c1=O |
| Relative Density. | 1.51 g/cm3 (Predicted) |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||
| Solubility Information | DMSO: 0.77 mg/mL (1.55 mM), Sonication and heating are recommended.  | ||||||||||
Solution Preparation Table | |||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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