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Gadolinium chloride

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Catalog No. T22795Cas No. 10138-52-0

Gadolinium chloride is a calcium-sensing receptor (CaSR) agonist

Gadolinium chloride

Gadolinium chloride

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Catalog No. T22795Cas No. 10138-52-0
Gadolinium chloride is a calcium-sensing receptor (CaSR) agonist
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
25 mg$41In StockIn Stock
50 mg$53In StockIn Stock
100 mg$82In StockIn Stock
200 mg$128In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Appearance:Solid
Color:White
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Product Introduction

Bioactivity
Description
Gadolinium chloride is a calcium-sensing receptor (CaSR) agonist
In vitro
Gadolinium chloride (GdCl ) , a well-known Kupffer/foam cell inhibitor, at late stages of NPC liver disease and compared it with NPC1 genetic rescue in hepatocytes in vivo.?GdCl treatment successfully blocked the endocytic capacity of hepatic Kupffer/foam measured by India ink endocytosis, decreased the levels CD68-A marker of Kupffer cells in the liver-and normalized the transaminase levels in serum of NPC mice to a similar extent to those obtained by genetic Npc1 rescue of liver cells.?Gadolinium salts are widely used as magnetic resonance imaging (MRI) contrasts.?This study opens the possibility of targeting foam cells with gadolinium or by other means for improving NPC liver disease.?Synopsis: Gadolinium chloride can effectively rescue some parameters of liver dysfunction in NPC mice and its potential use in patients should be carefully evaluated.
Chemical Properties
Molecular Weight263.61
FormulaCl3Gd
Cas No.10138-52-0
Smiles[Gd](Cl)(Cl)Cl
Relative Density.4.52 g/cm3
Storage & Solubility Information
StorageIn solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 7.5 mg/mL (28.45 mM), Sonication is recommended.
H2O: 9.85 mg/mL (37.37 mM), Sonication is recommended.
In Vivo Formulation
Saline: >10 mg/mL, Solution.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO/H2O
1mg5mg10mg50mg
1 mM3.7935 mL18.9674 mL37.9348 mL189.6741 mL
5 mM0.7587 mL3.7935 mL7.5870 mL37.9348 mL
10 mM0.3793 mL1.8967 mL3.7935 mL18.9674 mL
20 mM0.1897 mL0.9484 mL1.8967 mL9.4837 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

specificreceptorInhibitorinhibitH9c2GdCl-3GdCl3GdCl 3Gadolinium ChlorideGadoliniumCaSRcardiovascularCalcium-sensing receptorcalcium-sensing
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