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LY2787106
(Synonyms: Anti-Hepcidin/HAMP Antibody (LY2787106)) Copy Product Info
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Synonyms: Anti-Hepcidin/HAMP Antibody (LY2787106)
Catalog No. T9901A-1355 Copy Product Info
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LY2787106 is a humanized monoclonal antibody designed to neutralize bioactive human hepcidin-25. Hepcidin is the master hormonal regulator of systemic iron homeostasis, which limits iron release into the bloodstream by inducing the internalization and degradation of ferroportin, the only known cellular iron exporter. In states of chronic inflammation and cancer, abnormally elevated hepcidin causes iron sequestration. LY2787106 potently neutralizes circulating hepcidin, blocking its action on ferroportin and thereby mobilizing stored iron to increase serum iron levels and support erythropoiesis, specifically for managing cancer-associated anemia.
LY2787106
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $278 | Inquiry | Inquiry | |
| 5 mg | $838 | Inquiry | Inquiry | |
| 10 mg | $1,330 | Inquiry | Inquiry |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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| Description | LY2787106 is a humanized monoclonal antibody designed to neutralize bioactive human hepcidin-25. Hepcidin is the master hormonal regulator of systemic iron homeostasis, which limits iron release into the bloodstream by inducing the internalization and degradation of ferroportin, the only known cellular iron exporter. In states of chronic inflammation and cancer, abnormally elevated hepcidin causes iron sequestration. LY2787106 potently neutralizes circulating hepcidin, blocking its action on ferroportin and thereby mobilizing stored iron to increase serum iron levels and support erythropoiesis, specifically for managing cancer-associated anemia. |
| In vitro | LY2787106 binds to human hepcidin-25 with high affinity and specificity. In cell-based bioassays, the antibody effectively blocks hepcidin-induced degradation of ferroportin, maintaining cellular iron export capacity in a dose-dependent manner [1]. |
| In vivo | In pharmacological studies, LY2787106 demonstrated robust iron-mobilizing effects. Administration leads to a significant increase in serum iron and transferrin saturation (TSAT), reversing hepcidin-mediated hypoferremia in both healthy and disease models [1][2]. |
| Synonyms | Anti-Hepcidin/HAMP Antibody (LY2787106) |
| Reactivity | Human |
| Application | FACS Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Uniprot ID | |
| Target | Hepcidin/HAMP |
| Isotype | IgG4 (S228P) |
| Recommended Isotype Control |
| Storage | Store at low temperature Store at -20°C Shipping with blue ice/Shipping at ambient temperature. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: LY2787106 in vivo | LY2787106 in vitro
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