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Purpurogallin

Name: Purpurogallin
Brand: TargetMol
SKU: T16685
Price: 48 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16685Cas No. 569-77-7

Purpurogallin, a naturally occurring phenol extracted from Quercus spp. plants, exhibits potent xanthine oxidase inhibitory activity (IC50: 0.2 μM) and also possesses antioxidant and anti-inflammatory effects.

Purpurogallin

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Purity: 96.44%

Catalog No. T16685Cas No. 569-77-7

Pack Size	Price	Availability
5 mg	$48	In Stock
10 mg	$82	Backorder
25 mg	$124	Backorder
50 mg	$166	Backorder
100 mg	$249	Backorder
1 mL x 10 mM (in DMSO)	$56	In Stock

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Purity:96.44%

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Product Introduction

Bioactivity

Description	Purpurogallin, a naturally occurring phenol extracted from Quercus spp. plants, exhibits potent xanthine oxidase inhibitory activity (IC50: 0.2 μM) and also possesses antioxidant and anti-inflammatory effects.
Targets&IC50	XO:0.2 μM
In vitro	Purpurogallin (100 μM; 75-120 minutes; BV2 murine microglial cells) exhibits anti-inflammatory properties by suppressing the phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase signaling pathways in LPS-stimulated BV2 microglial cells. Purpurogallin (50 or 100 μM; 7 or 25 hours; BV2 murine microglial cells) treatment decreases the production of pro-inflammatory cytokines, including interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) by suppressing their mRNA and protein expression in LPS-stimulated BV2 microglial cells[1].
In vivo	By the dual effect of inhibiting IL-6 and TNF-α mRNA expression and reducing HMGB1 protein and mRNA expression, Purpurogallin (100-400?μg/kg; intraperitoneal injection; for 48 or 72 hours; male Sprague-Dawley rats) exerts its neuroinflammation effect [2].

Chemical Properties

Molecular Weight	220.18
Formula	C₁₁H₈O₅
Cas No.	569-77-7
Smiles	Oc1cc2cccc(O)c(=O)c2c(O)c1O
Relative Density.	1.74g/cm3
Color	Yellow
Appearance	solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 125 mg/mL (567.72 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.5417 mL	22.7087 mL	45.4174 mL	227.0869 mL
5 mM	0.9083 mL	4.5417 mL	9.0835 mL	45.4174 mL
10 mM	0.4542 mL	2.2709 mL	4.5417 mL	22.7087 mL
20 mM	0.2271 mL	1.1354 mL	2.2709 mL	11.3543 mL
50 mM	0.0908 mL	0.4542 mL	0.9083 mL	4.5417 mL
100 mM	0.0454 mL	0.2271 mL	0.4542 mL	2.2709 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc