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Jatrorrhizine
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Catalog No. T3933Cas No. 3621-38-3
Alias Yatrorizine, neprotin
Jatrorrhizine (neprotin) is a protoberberine alkaloid isolated from Enantia chlorantha (Annonaceae) and other species. It was found to have antimicrobial and antifungal activity. It binds and noncompetitively inhibits monoamine oxidase (IC50 4 micromolar for MAO-A and 62 for MAO-B).
Jatrorrhizine
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Purity: 99.06%
Catalog No. T3933Alias Yatrorizine, neprotinCas No. 3621-38-3
Jatrorrhizine (neprotin) is a protoberberine alkaloid isolated from Enantia chlorantha (Annonaceae) and other species. It was found to have antimicrobial and antifungal activity. It binds and noncompetitively inhibits monoamine oxidase (IC50 4 micromolar for MAO-A and 62 for MAO-B).
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 2 mg | $33 | In Stock | In Stock | |
| 5 mg | $50 | In Stock | In Stock | |
| 10 mg | $77 | In Stock | In Stock | |
| 25 mg | $136 | In Stock | In Stock | |
| 50 mg | $198 | In Stock | In Stock | |
| 100 mg | $298 | In Stock | In Stock | |
| 200 mg | $442 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.06%
Color:Black
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Product Introduction
Jatrorrhizine AI Summary
Jatrorrhizine inhibits human CYP3A4 enzyme activity, particularly the oxidation of nifedipine, with an IC50 value of 2100.0 nM. It also demonstrates inhibition of recombinant LSD1, with an IC50 of 1550.0 nM using H3K4me2 as a substrate. The compound exhibits a diverse range of bioactivities, including modulation of Lamin A splicing at 11220.2 nM, inhibition of Human Jumonji Domain Containing 2E (JMJD2E) at 12589.3 nM, and inhibition of ATPase activity of Tag at 4220.0 nM. Additionally, Jatrorrhizine enhances SMN2 splice variant expression with a potency of 3162.3 nM, inhibits Tau fibril formation at 15848.9 nM, and affects Candida albicans growth with an EC50 of 2906.0 nM. It also inhibits human alpha-Glucosidase from spleen homogenate with a potency of 7079.5 nM and inhibits ROR gamma transcriptional activity at 35481.3 nM. Moreover, it shows activities as an inhibitor of neuraminidase enzymes, including Clostridium perfringens and Influenza A virus neuraminidases (H1N1 and H5N1), with higher IC50 values of 37000.0 nM, 66200.0 nM, and 76300.0 nM, respectively.
Furthermore, Jatrorrhizine displays antiamoebic activity against Entamoeba histolytica with an IC50 of 27.95 µg/mL and has antimycobacterial activity against Mycobacterium sp. with an MIC of less than 100.0 µg/mL. It also exhibits synergistic antibacterial activity against methicillin-susceptible Staphylococcus aureus 1199B, reducing norfloxacin MIC at 64 µg/mL and a FICI of 0.375. Overall, Jatrorrhizine shows a range of biological activities, making it a compound of interest across multiple therapeutic areas..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Jatrorrhizine (neprotin) is a protoberberine alkaloid isolated from Enantia chlorantha (Annonaceae) and other species. It was found to have antimicrobial and antifungal activity. It binds and noncompetitively inhibits monoamine oxidase (IC50 4 micromolar for MAO-A and 62 for MAO-B). |
| Targets&IC50 | MAO-A:4 μm, MAO-B:62μm |
| Synonyms | Yatrorizine, neprotin |
| Molecular Weight | 338.38 |
| Formula | C20H20NO4 |
| Cas No. | 3621-38-3 |
| Smiles | O(C)C=1C=C2C=3[N+](=CC=4C(C3)=CC=C(OC)C4OC)CCC2=CC1O |
| Relative Density. | no data available |
| Storage | keep away from moisture,keep away from direct sunlight | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.: Soluble DMSO: 6.67 mg/mL (19.71 mM), Sonication is recommended.  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
Serotonin Receptorquaternary isoquinolineneuroprotectiveMAO-BMAO-AJatrorrhizineInhibitorinhibitfalciparumE. histolyticadepressive disorderCytotoxicCholinesterase (ChE)Bacterialantiplasmodialantioxidantantimicrobialantidepressant-likeantidepressantantiamoebicAlzheimer's diseasealkaloidAChE5-hydroxytryptamine Receptor5HTReceptor5-HT Receptor5HT Receptor
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