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Paroxetine

Name: Paroxetine
Brand: TargetMol
SKU: T8708
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T8708Cas No. 61869-08-7

Paroxetine is a inhibitor of serotonin uptake that is effective in the treatment of depression.

Paroxetine

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Purity: 99.97%

Catalog No. T8708Cas No. 61869-08-7

Paroxetine is a inhibitor of serotonin uptake that is effective in the treatment of depression.

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$34	In Stock	In Stock
100 mg	$55	In Stock	In Stock
500 mg	$162	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.97%

Color:Transparent to Yellow

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COA HNMR LCMS

Product Introduction

Paroxetine AI Summary

Paroxetine exhibits potent and diverse bioactivities spanning serotonin reuptake inhibition, antibacterial properties, and antiviral effects. It shows high affinity for serotonin transporters (SERT) with Ki values ranging from 0.08 to 0.77 nM and demonstrates substantial inhibition of serotonin reuptake in various assays, indicating potential as a selective serotonin reuptake inhibitor (SSRI). Additionally, it has moderate affinity for norepinephrine transporters (NET) and lower affinity for dopamine transporters (DAT), highlighting its selectivity for serotonin. In antibacterial studies, Paroxetine significantly reduces the Minimum Inhibitory Concentration (MIC) of Norfloxacin against Staphylococcus aureus by 8-fold, suggesting its potential as an efflux pump inhibitor. Furthermore, Paroxetine shows antiviral activity, particularly against SARS-CoV-2 and Ebola virus, inhibiting viral entry and cytotoxicity in cellular assays. It also exhibits pharmacokinetic properties such as high plasma protein binding and a moderate volume of distribution, alongside a pKa of 9.51, indicating its ionization profile in biological systems. These comprehensive activities suggest that Paroxetine could serve as a multifaceted therapeutic agent targeting neurotransmitter transport systems, bacterial resistance mechanisms, and viral infections..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Paroxetine is a inhibitor of serotonin uptake that is effective in the treatment of depression.

Chemical Properties

Molecular Weight	329.37
Formula	C₁₉H₂₀FNO₃
Cas No.	61869-08-7
Smiles	C(OC=1C=C2C(=CC1)OCO2)[C@H]3[C@@H](CCNC3)C4=CC=C(F)C=C4
Relative Density.	1.1844 g/cm3 (Estimated)

Storage & Solubility Information

Storage

store under nitrogen | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (182.17 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.07 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0361 mL	15.1805 mL	30.3610 mL	151.8050 mL
5 mM	0.6072 mL	3.0361 mL	6.0722 mL	30.3610 mL
10 mM	0.3036 mL	1.5180 mL	3.0361 mL	15.1805 mL
20 mM	0.1518 mL	0.7590 mL	1.5180 mL	7.5902 mL
50 mM	0.0607 mL	0.3036 mL	0.6072 mL	3.0361 mL
100 mM	0.0304 mL	0.1518 mL	0.3036 mL	1.5180 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc