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VY-3-135
🥰Excellent
Catalog No. T9732Cas No. 1824637-41-3
VY-3-135 is an orally active, stable and specific acetyl-CoA synthetase 2 (ACSS2) inhibitor with IC50 of 44 nM, showing no inhibitory activity against recombinant human ACSS1 or ACSS3. VY-3-135 can effectively inhibit ACSS2-dependent fatty acid metabolism but has no effect on gene expression in tumors.
VY-3-135
🥰Excellent
Purity: 99.79%
Catalog No. T9732Cas No. 1824637-41-3
VY-3-135 is an orally active, stable and specific acetyl-CoA synthetase 2 (ACSS2) inhibitor with IC50 of 44 nM, showing no inhibitory activity against recombinant human ACSS1 or ACSS3. VY-3-135 can effectively inhibit ACSS2-dependent fatty acid metabolism but has no effect on gene expression in tumors.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $97 | In Stock | |
| 5 mg | $197 | In Stock | |
| 10 mg | $328 | In Stock | |
| 25 mg | $556 | In Stock | |
| 50 mg | $765 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $198 | In Stock |
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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Purity:99.79%
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Product Introduction
Bioactivity
Chemical Properties
| Description | VY-3-135 is an orally active, stable and specific acetyl-CoA synthetase 2 (ACSS2) inhibitor with IC50 of 44 nM, showing no inhibitory activity against recombinant human ACSS1 or ACSS3. VY-3-135 can effectively inhibit ACSS2-dependent fatty acid metabolism but has no effect on gene expression in tumors. |
| In vitro | METHODS: BT474 cells were treated with VY-3-135 (0.01, 0.1, 1 μM), and SKBr3 cells were treated with VY-3-135 (1 μM). RESULTS VY-3-135 completely blocked fatty acid synthesis from acetate in SKBr3 cells. VY-3-135 is an effective targeted ACSS2 inhibitor in cells. [1] |
| In vivo | METHODS: BT474-transplanted mice were randomly assigned and treated with VY-3-135 (100 mg/kg) by intraperitoneal (IP) injection or oral gavage. Tumor size was measured in mice. RESULTS VY-3-135 inhibited the growth of MDA-MB-468 (ACSS2 high) tumors but had no effect on WHIM12 (ACSS2 low) tumors. [1] |
| Molecular Weight | 429.51 |
| Formula | C26H27N3O3 |
| Cas No. | 1824637-41-3 |
| Smiles | CCn1c(nc2ccc(cc12)C(=O)NC[C@@H](C)O)C(O)(c1ccccc1)c1ccccc1 |
| Relative Density. | 1.21 g/cm3 (Predicted) |
| Color | White |
| Appearance | Solid |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (116.41 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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