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VY-3-135

Name: VY-3-135
Brand: TargetMol
SKU: T9732
Price: 97 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9732Cas No. 1824637-41-3

VY-3-135 is an orally active, stable and specific acetyl-CoA synthetase 2 (ACSS2) inhibitor with IC50 of 44 nM, showing no inhibitory activity against recombinant human ACSS1 or ACSS3. VY-3-135 can effectively inhibit ACSS2-dependent fatty acid metabolism but has no effect on gene expression in tumors.

VY-3-135

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Purity: 99.79%

Catalog No. T9732Cas No. 1824637-41-3

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$97	In Stock	In Stock
5 mg	$197	In Stock	In Stock
10 mg	$328	In Stock	In Stock
25 mg	$529	In Stock	In Stock
50 mg	$728	In Stock	In Stock
100 mg	$993	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$193	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.79%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

VY-3-135 AI Summary

VY-3-135 exhibits strong inhibitory activity against ACSS2, both in insect cells and human HCT116 cells, with an IC50 value of less than or equal to 50.0 nM in both assays. Additionally, it demonstrates significant antitumor efficacy against human 786-0 cells xenografted into SCID/Beige mice, leading to a substantial reduction in tumor size after being administered orally at a dosage of 200 mg/kg, twice daily for 20 days. The treatment resulted in an observed tumor volume of 281.1 mm³ compared to the control group, which had a tumor volume of 623.1 ± 95.1 mm³, underscoring the potent antitumor effects of VY-3-135..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	VY-3-135 is an orally active, stable and specific acetyl-CoA synthetase 2 (ACSS2) inhibitor with IC50 of 44 nM, showing no inhibitory activity against recombinant human ACSS1 or ACSS3. VY-3-135 can effectively inhibit ACSS2-dependent fatty acid metabolism but has no effect on gene expression in tumors.
In vitro	METHODS: BT474 cells were treated with VY-3-135 (0.01, 0.1, 1 μM), and SKBr3 cells were treated with VY-3-135 (1 μM). RESULTS VY-3-135 completely blocked fatty acid synthesis from acetate in SKBr3 cells. VY-3-135 is an effective targeted ACSS2 inhibitor in cells. [1]
In vivo	METHODS: BT474-transplanted mice were randomly assigned and treated with VY-3-135 (100 mg/kg) by intraperitoneal (IP) injection or oral gavage. Tumor size was measured in mice. RESULTS VY-3-135 inhibited the growth of MDA-MB-468 (ACSS2 high) tumors but had no effect on WHIM12 (ACSS2 low) tumors. [1]

Chemical Properties

Molecular Weight	429.51
Formula	C₂₆H₂₇N₃O₃
Cas No.	1824637-41-3
Smiles	CCn1c(nc2ccc(cc12)C(=O)NC[C@@H](C)O)C(O)(c1ccccc1)c1ccccc1
Relative Density.	1.21 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 46.67 mg/mL (108.66 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.66 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3282 mL	11.6412 mL	23.2823 mL	116.4117 mL
5 mM	0.4656 mL	2.3282 mL	4.6565 mL	23.2823 mL
10 mM	0.2328 mL	1.1641 mL	2.3282 mL	11.6412 mL
20 mM	0.1164 mL	0.5821 mL	1.1641 mL	5.8206 mL
50 mM	0.0466 mL	0.2328 mL	0.4656 mL	2.3282 mL
100 mM	0.0233 mL	0.1164 mL	0.2328 mL	1.1641 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc