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AES-135

Name: AES-135
Brand: TargetMol
SKU: T10255
Price: 76 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T10255Cas No. 2361659-61-0

AES-135 is a potent HDAC inhibitor, inhibits HDAC3, HDAC6, HDAC11 (IC50s: 654, 190, and 636 nM) with anti-tumor activity.

AES-135

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Purity: 97.72%

Catalog No. T10255Cas No. 2361659-61-0

AES-135 is a potent HDAC inhibitor, inhibits HDAC3, HDAC6, HDAC11 (IC50s: 654, 190, and 636 nM) with anti-tumor activity.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$76	In Stock	In Stock
5 mg	$163	In Stock	In Stock
10 mg	$278	In Stock	In Stock
25 mg	$472	In Stock	In Stock
50 mg	$648	In Stock	In Stock
100 mg	$893	-	In Stock
1 mL x 10 mM (in DMSO)	$250	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:97.72%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

AES-135 AI Summary

AES-135 shows bioactivity as a histone deacetylase (HDAC) inhibitor, particularly against HDAC3, HDAC6, and HDAC11, with IC50 values of 654.0 nM, 190.0 nM, and 636.0 nM respectively. It exhibits significant cytotoxicity against various human cell lines, including MV4-11, MOLM13, MDA-MB-231, MDA-MB-468, and MRC9, with IC50 values ranging from 1880.0 nM to 19200.0 nM. The compound demonstrates strong protein binding in CD-1 mouse plasma (PPB = 99.6%), moderate stability in CD-1 mouse hepatocytes (Stability = 20.0%), and high permeability with log Pe = 7.73 and Papp = 0.27 x 10^-6 cm/s. Additionally, it shows no significant inhibition of HDAC1, HDAC4, and HDAC8 at 10 μM concentration. In various models, AES-135 exhibits moderate half-life, appropriate clearance, and good bioavailability, as well as antitumor activity against allografted mouse pancreatic cancer cells in mice, demonstrating its potential as a therapeutic agent..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	AES-135 is a potent HDAC inhibitor, inhibits HDAC3, HDAC6, HDAC11 (IC50s: 654, 190, and 636 nM) with anti-tumor activity.
Targets&IC50	HDAC11:636 nM, HDAC3:654 nM, HDAC8:1100 nM, HDAC6:190 nM

Chemical Properties

Molecular Weight	693.66
Formula	C₃₃H₂₉F₆N₃O₅S
Cas No.	2361659-61-0
Smiles	CC(C)(C)c1ccc(CN(C(=O)CN(Cc2c(F)c(F)c(F)c(F)c2F)S(=O)(=O)c2ccc(F)cc2)c2ccc(cc2)C(=O)NO)cc1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (144.16 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 3.3 mg/mL (4.76 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.4416 mL	7.2081 mL	14.4163 mL	72.0814 mL
5 mM	0.2883 mL	1.4416 mL	2.8833 mL	14.4163 mL
10 mM	0.1442 mL	0.7208 mL	1.4416 mL	7.2081 mL
20 mM	0.0721 mL	0.3604 mL	0.7208 mL	3.6041 mL
50 mM	0.0288 mL	0.1442 mL	0.2883 mL	1.4416 mL
100 mM	0.0144 mL	0.0721 mL	0.1442 mL	0.7208 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc