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AES-135

Name: AES-135
Brand: TargetMol
SKU: T10255
Price: 76 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T10255Cas No. 2361659-61-0

AES-135 is a potent HDAC inhibitor, inhibits HDAC3, HDAC6, HDAC11 (IC50s: 654, 190, and 636 nM) with anti-tumor activity.

AES-135

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Purity: 97.72%

Catalog No. T10255Cas No. 2361659-61-0

AES-135 is a potent HDAC inhibitor, inhibits HDAC3, HDAC6, HDAC11 (IC50s: 654, 190, and 636 nM) with anti-tumor activity.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$76	In Stock	In Stock
5 mg	$163	In Stock	In Stock
10 mg	$278	In Stock	In Stock
25 mg	$472	In Stock	In Stock
50 mg	$648	In Stock	In Stock
100 mg	$893	-	In Stock
1 mL x 10 mM (in DMSO)	$250	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:97.72%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	AES-135 is a potent HDAC inhibitor, inhibits HDAC3, HDAC6, HDAC11 (IC50s: 654, 190, and 636 nM) with anti-tumor activity.
Targets&IC50	HDAC8:1100 nM, HDAC6:190 nM, HDAC3:654 nM, HDAC11:636 nM

Chemical Properties

Molecular Weight	693.66
Formula	C₃₃H₂₉F₆N₃O₅S
Cas No.	2361659-61-0
Smiles	CC(C)(C)c1ccc(CN(C(=O)CN(Cc2c(F)c(F)c(F)c(F)c2F)S(=O)(=O)c2ccc(F)cc2)c2ccc(cc2)C(=O)NO)cc1
Relative Density.	no data available
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (144.16 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 3.3 mg/mL (4.76 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.4416 mL	7.2081 mL	14.4163 mL	72.0814 mL
5 mM	0.2883 mL	1.4416 mL	2.8833 mL	14.4163 mL
10 mM	0.1442 mL	0.7208 mL	1.4416 mL	7.2081 mL
20 mM	0.0721 mL	0.3604 mL	0.7208 mL	3.6041 mL
50 mM	0.0288 mL	0.1442 mL	0.2883 mL	1.4416 mL
100 mM	0.0144 mL	0.0721 mL	0.1442 mL	0.7208 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc