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Docosahexaenoic Acid

Name: Docosahexaenoic Acid
Brand: TargetMol
SKU: T5369
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5369Cas No. 6217-54-5

Alias DHA, Cervonic acid

Docosahexaenoic Acid (DHA) is an essential omega-3 fatty acid prevalent in the brain and retina.

Docosahexaenoic Acid

🥰Excellent

Purity: 99.89%

Catalog No. T5369Alias DHA, Cervonic acidCas No. 6217-54-5

Docosahexaenoic Acid (DHA) is an essential omega-3 fatty acid prevalent in the brain and retina.

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$34	In Stock	In Stock
100 mg	$50	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.89%

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	Docosahexaenoic Acid (DHA) is an essential omega-3 fatty acid prevalent in the brain and retina.
Targets&IC50	Bradykinin (RCASM cells):0.23 ± 0.03 μM (EC50), DHL-4 cells:5.2 µM, HL-60 cells:74 μM
In vitro	When monocytes were differentiated to dendritic cells (DCs) in the presence of docosahexaenoic acid (DHA), the expression of costimulatory and antigen presentation markers was altered in a concentration-dependent way, positively or negatively, depending on the markers tested and the maturation stage of the DCs. DHA-treated, mature DCs showed inhibition of IL-6 expression and IL-10 and IL-12 secretion, and their lymphoproliferative stimulation capacity was impaired [1].
In vivo	An experimental model of PD was created by four intraperitoneal injections of MPTP (4 × 20 mg/kg, at 12h intervals). Docosahexaenoic acid was given daily by gavage for 4 weeks (36 mg/kg/day). The number of apoptotic dopaminergic cells significantly increased in MPTP-treated mice compared to controls. Although DHA significantly diminished the number of cell deaths in MPTP-treated mice, it did not improve the decreased motor activity observed in the experimental PD model. Docosahexaenoic acid significantly diminished the amount of cell death in the MPTP+DHA group as compared to the MPTP group [2].
Synonyms	DHA, Cervonic acid

Chemical Properties

Molecular Weight	328.49
Formula	C₂₂H₃₂O₂
Cas No.	6217-54-5
Smiles	CCC=CCC=CCC=CCC=CCC=CCC=CCCC(O)=O
Relative Density.	0.943 g/cm3
Color	Transparent
Appearance	Liquid

Storage & Solubility Information

Storage

store at low temperature,keep away from moisture,store under nitrogen | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 30 mg/mL (91.33 mM), Sonication is recommended.

DMSO: 100 mg/mL (304.42 mM), Sonication is recommended.

H2O: 5 mg/mL (15.22 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (12.18 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0442 mL	15.2212 mL	30.4423 mL	152.2116 mL
5 mM	0.6088 mL	3.0442 mL	6.0885 mL	30.4423 mL
10 mM	0.3044 mL	1.5221 mL	3.0442 mL	15.2212 mL

Ethanol/DMSO

	1mg	5mg	10mg	50mg
20 mM	0.1522 mL	0.7611 mL	1.5221 mL	7.6106 mL
50 mM	0.0609 mL	0.3044 mL	0.6088 mL	3.0442 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0304 mL	0.1522 mL	0.3044 mL	1.5221 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc