Anti-EphB2 Polyclonal Antibody

Name: Anti-EphB2 Polyclonal Antibody
Brand: TargetMol
SKU: TMAB-00625
Rating: 4.5 (1 reviews)

(Synonyms: Tyro5, PCBC, Hek5, ERK, EPHT3, EPH receptor B2, EK5, DRT, CAPB) Copy Product Info

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Synonyms: Tyro5, PCBC, Hek5, ERK, EPHT3, EPH receptor B2, EK5, DRT, CAPB

Catalog No. TMAB-00625 Copy Product Info

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Anti-EphB2 Polyclonal Antibody is a Rabbit antibody targeting EphB2. Anti-EphB2 Polyclonal Antibody can be used in IF,IHC-Fr,IHC-P,WB.

Anti-EphB2 Polyclonal Antibody

Pack Size	Price	USA Stock	Global Stock
50 μL	$222	7-10 days	7-10 days
100 μL	$372	7-10 days	7-10 days
200 μL	$528	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Instruction Manual of Detection Antibody

Product Introduction

Bioactivity

Description	Anti-EphB2 Polyclonal Antibody is a Rabbit antibody targeting EphB2. Anti-EphB2 Polyclonal Antibody can be used in IF,IHC-Fr,IHC-P,WB.
Synonyms	Tyro5, PCBC, Hek5, ERK, EPHT3, EPH receptor B2, EK5, DRT, CAPB
Ig Type	IgG
Reactivity	Rat,Mouse,Human (predicted:Dog,Chicken)

Application	IF IHC-Fr IHC-P WB
Recommended Dose	WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
Antibody Type	Polyclonal
Host Species	Rabbit
Subcellular Localization	Cell membrane; Single-pass type I membrane protein. Cell projection, axon. Cell projection, dendrite.
Tissue Specificity	Brain, heart, lung, kidney, placenta, pancreas, liver and skeletal muscle. Preferentially expressed in fetal brain.
Construction	Polyclonal Antibody
Purification	Protein A purified
Appearance	Liquid
Formulation	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration	1 mg/mL
Research Background	This gene encodes a member of the Eph receptor family of receptor tyrosine kinase transmembrane glycoproteins. These receptors are composed of an N-terminal glycosylated ligand-binding domain, a transmembrane region and an intracellular kinase domain. They bind ligands called ephrins and are involved in diverse cellular processes including motility, division, and differentiation. A distinguishing characteristic of Eph-ephrin signaling is that both receptors and ligands are competent to transduce a signaling cascade, resulting in bidirectional signaling. This protein belongs to a subgroup of the Eph receptors called EphB. Proteins of this subgroup are distinguished from other members of the family by sequence homology and preferential binding affinity for membrane-bound ephrin-B ligands. Allelic variants are associated with prostate and brain cancer susceptibility. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]

Antigen Details

Immunogen	KLH conjugated synthetic peptide: human EphB2
Antigen Species	Human
Gene Name	EPHB2
Gene ID	2048
Protein Name	Ephrin type-B receptor 2
Uniprot ID	P29323
Biology Area	Eph Receptors,Growth Cone,Axonal Guidance Proteins,Kinases,Tyrosine Kinase Receptors,Receptor Tyrosine Kinases
Function	Receptor for members of the ephrin-B family. Phosphorylates ARHGEF15, leading to its ubiquitination and degradation by the proteasome which promotes EFNB1-dependent synapse formation. Can function in aspects of retinal ganglion cell axon guidance to the optic disk even when lacking its tyrosine kinase domain. Acts as a tumor suppressor.