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Metaproterenol hemisulfate

Name: Metaproterenol hemisulfate
Brand: TargetMol
SKU: T0277
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0277Cas No. 5874-97-5

Alias Orciprenaline sulfate, Metaproterenol Sulfate

Metaproterenol hemisulfate (Orciprenaline sulfate) is a beta-2 adrenergic agonist used in the treatment of ASTHMA and BRONCHIAL SPASM.

Metaproterenol hemisulfate

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Purity: 99.74%

Catalog No. T0277Alias Orciprenaline sulfate, Metaproterenol SulfateCas No. 5874-97-5

Metaproterenol hemisulfate (Orciprenaline sulfate) is a beta-2 adrenergic agonist used in the treatment of ASTHMA and BRONCHIAL SPASM.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$30	In Stock	In Stock
50 mg	$40	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$44	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.74%

Appearance:Solid

Color:White

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COA HPLC HNMR

Product Introduction

Metaproterenol hemisulfate AI Summary

Metaproterenol hemisulfate exhibits bioactivities as an inhibitor in various assays. It has demonstrated potency in modulating Lamin A splicing with an IC50 of 5623.4 nM and inhibiting Human Apurinic/apyrimidinic Endonuclease 1 (APE1) with potencies of 15848.9 nM and 1.1 nM in different assays. Additionally, it inhibits Bloom's syndrome helicase (BLM) at 2511.9 nM, Histone Lysine Methyltransferase G9a at 25118.9 nM, and blocks the interaction between CBF-beta and RUNX1, relevant for the treatment of Acute Myeloid Leukemia, at 7079.5 nM. For Ebola Virus entry inhibition, it has AC50 values of 39.81 μM and 39810.7 nM in different assays. However, Metaproterenol hemisulfate shows limited bioactivity in inhibiting cell viability in Vero E6 cells infected with SARS-CoV-2 (strain BavPat1) at an MOI of 0.002, with an inhibition index of 0.06285, indicating weaker activity compared to the control, arbidol..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Metaproterenol hemisulfate (Orciprenaline sulfate) is a beta-2 adrenergic agonist used in the treatment of ASTHMA and BRONCHIAL SPASM.
Targets&IC50	β2-adrenoceptor:68 nM (IC50)
Synonyms	Orciprenaline sulfate, Metaproterenol Sulfate

Chemical Properties

Molecular Weight	260.3
Formula	C₁₁H₁₇NO₃·0·5H₂O₄S
Cas No.	5874-97-5
Smiles	c1(cc(cc(c1)C(CNC(C)C)O)O)O.S(=O)(=O)(O)O.c1(cc(cc(c1)C(CNC(C)C)O)O)O
Relative Density.	1.199g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 83.3 mg/mL (320.02 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (3.84 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.8417 mL	19.2086 mL	38.4172 mL	192.0861 mL
5 mM	0.7683 mL	3.8417 mL	7.6834 mL	38.4172 mL
10 mM	0.3842 mL	1.9209 mL	3.8417 mL	19.2086 mL
20 mM	0.1921 mL	0.9604 mL	1.9209 mL	9.6043 mL
50 mM	0.0768 mL	0.3842 mL	0.7683 mL	3.8417 mL
100 mM	0.0384 mL	0.1921 mL	0.3842 mL	1.9209 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc