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NLRP3-IN-2

🥰Excellent
Catalog No. T3230Cas No. 16673-34-0
Alias NLRP3 Inflammasome Inhibitor I, 5-Chloro-N-(p-sulfamoylphenethyl)-o-anisamide

NLRP3-IN-2 (5-Chloro-N-(p-sulfamoylphenethyl)-o-anisamide), an intermediate capable of synthesizing glibenclamide, exerts an inhibitory effect on the formation of NLRP3 inflammatory vesicles in cardiomyocytes, limiting infarct size after myocardial ischemia/reperfusion in mice and has no effect on metabolism.

NLRP3-IN-2

NLRP3-IN-2

🥰Excellent
Purity: 98.98%
Catalog No. T3230Alias NLRP3 Inflammasome Inhibitor I, 5-Chloro-N-(p-sulfamoylphenethyl)-o-anisamideCas No. 16673-34-0
NLRP3-IN-2 (5-Chloro-N-(p-sulfamoylphenethyl)-o-anisamide), an intermediate capable of synthesizing glibenclamide, exerts an inhibitory effect on the formation of NLRP3 inflammatory vesicles in cardiomyocytes, limiting infarct size after myocardial ischemia/reperfusion in mice and has no effect on metabolism.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
25 mg$31In StockIn Stock
50 mg$41In StockIn Stock
100 mg$53In StockIn Stock
500 mg$123In StockIn Stock
1 g$179In StockIn Stock
1 mL x 10 mM (in DMSO)$45In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:98.98%
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Product Introduction

Bioactivity
Description
NLRP3-IN-2 (5-Chloro-N-(p-sulfamoylphenethyl)-o-anisamide), an intermediate capable of synthesizing glibenclamide, exerts an inhibitory effect on the formation of NLRP3 inflammatory vesicles in cardiomyocytes, limiting infarct size after myocardial ischemia/reperfusion in mice and has no effect on metabolism.
SynonymsNLRP3 Inflammasome Inhibitor I, 5-Chloro-N-(p-sulfamoylphenethyl)-o-anisamide
Chemical Properties
Molecular Weight368.84
FormulaC16H17ClN2O4S
Cas No.16673-34-0
SmilesCOc1ccc(Cl)cc1C(=O)NCCc1ccc(cc1)S(N)(=O)=O
Relative Density.1.356g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 55 mg/mL (149.12 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.42 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.7112 mL13.5560 mL27.1120 mL135.5601 mL
5 mM0.5422 mL2.7112 mL5.4224 mL27.1120 mL
10 mM0.2711 mL1.3556 mL2.7112 mL13.5560 mL
20 mM0.1356 mL0.6778 mL1.3556 mL6.7780 mL
50 mM0.0542 mL0.2711 mL0.5422 mL2.7112 mL
100 mM0.0271 mL0.1356 mL0.2711 mL1.3556 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

reperfusionNODlikeReceptor(NLR)NODlikeReceptorNOD-like Receptor (NLR)NODlike Receptor (NLR)NOD-like ReceptorNLRP3-IN-2NLRP-3-IN-2NLRP3IN2NLRP3 IN 2NLRP3NLRmyocardialischemiaInhibitorinhibitinflammasomeinfarctionacute
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