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Anti-IQSEC3 Polyclonal Antibody

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Catalog No. TMAB-07784

Anti-IQSEC3 Polyclonal Antibody is a Rabbit antibody targeting IQSEC3. Anti-IQSEC3 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.

Anti-IQSEC3 Polyclonal Antibody

Anti-IQSEC3 Polyclonal Antibody

😃Good
Catalog No. TMAB-07784
Anti-IQSEC3 Polyclonal Antibody is a Rabbit antibody targeting IQSEC3. Anti-IQSEC3 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
50 μL$2217-10 days7-10 days
100 μL$3717-10 days7-10 days
200 μL$5297-10 days7-10 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Anti-IQSEC3 Polyclonal Antibody is a Rabbit antibody targeting IQSEC3. Anti-IQSEC3 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Ig Type
IgG
Reactivity
Rat (predicted:Human,Mouse)
Application
Recommended Dose
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
Antibody Type
Polyclonal
Host SpeciesRabbit
Subcellular LocalizationCytoplasm.
Tissue SpecificityExpressed specifically in the adult brain, predominantly in the cerebral cortex and the olfactory bulb, but not in the fetal brain. Expressed only in mature neurons, but not in undifferentiated neural stem precursor cells (NSPCs), nor in glioma cells.
ConstructionPolyclonal Antibody
PurificationProtein A purified
AppearanceLiquid
FormulationPreservative: 0.02% Proclin300, Constituents: 1% BSA, 0.01M PBS, pH7.4.
Concentration1mg/ml
Research BackgroundIQSEC3 (IQ motif and SEC7 domain-containing protein 3), also known as KIAA1110, is a 1,182 amino acid protein that belongs to the BRAG family. Localizing to the cytoplasm, IQSEC3 is expressed predominantly in adult brain, where it is observed predominantly in the cerebral cortex and olfactory bulb, with no expression found in the fetal brain. IQSEC3 contains an IQ domain, a PH domain and a SEC7 domain, and interacts with SAP 97 and PSD-95. Acting as a guanine nucleotide exchange factor (GEF) for ARF1, IQSEC3 is encoded by a gene that maps to human chromosome 12p13.33 and mouse chromosome 6 F1. Mutations to the gene encoding IQSEC2 have been linked to non-syndromic X-linked intellectual disability, while both IQSEC1 and IQSEC3 may be candidates for autosomal ID screening. IQSEC3 exists as two alternatively spliced isoforms.
Antigen Details
Immunogen
KLH conjugated synthetic peptide: human IQSEC3
Antigen Species
Human
Gene Name
IQSEC3
Gene ID
Protein Name
IQ motif and SEC7 domain-containing protein 3
Uniprot ID
Function
Acts as a guanine nucleotide exchange factor (GEF) for ARF1.
Chemical Properties
Molecular WeightTheoretical: 127 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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