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Pikamilone (Synonyms: Picamilon, Nicotinoyl-GABA)

Name: Pikamilone
Brand: TargetMol
SKU: T3290
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T3290 Copy Product Info

Purity: 99.38%

🥰Excellent

Pikamilone (Picamilon) is an intelligent medicine.

Pikamilone

Copy Product Info

🥰Excellent

Catalog No. T3290

Synonyms Picamilon, Nicotinoyl-GABA

Pikamilone (Picamilon) is an intelligent medicine.

Cas No. 34562-97-5

Pack Size	Price	USA Stock	Global Stock	Quantity
200 mg	$29	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Purity:99.38%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Pikamilone AI Summary

Pikamilone exhibits antiviral activity against SARS-CoV-2. It reduces SARS-CoV-2 induced cytotoxicity in Caco-2 cells by -5.9% at a 10 µM concentration after 48 hours, and in VERO-6 cells, it shows inhibitory effects ranging from 0.09% to 0.29% under similar conditions. Additionally, Pikamilone inhibits the SARS-CoV-2 3CL-Pro protease with inhibition percentages of 28.03% and 3.319% at 20 µM as measured by a FRET assay. Despite its antiviral potential, the compound exhibits inconsistent inhibitory activity in human HDAC6 enzymatic assays, showing 28.69% inhibition with a commercial peptide substrate and -15.27% with a custom peptide substrate. The IC50 values indicate limited effectiveness at higher concentrations, being greater than 20000.0 nM and 19952.62 nM in VERO-6 cells..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Pikamilone (Picamilon) is an intelligent medicine.
Synonyms	Picamilon, Nicotinoyl-GABA

Chemical Properties

Molecular Weight	208.21
Formula	C₁₀H₁₂N₂O₃
Cas No.	34562-97-5
Smiles	OC(=O)CCCNC(=O)C1=CC=CN=C1
Relative Density.	1.245 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 30 mg/mL (144.09 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.8028 mL	24.0142 mL	48.0284 mL	240.1422 mL
5 mM	0.9606 mL	4.8028 mL	9.6057 mL	48.0284 mL
10 mM	0.4803 mL	2.4014 mL	4.8028 mL	24.0142 mL
20 mM	0.2401 mL	1.2007 mL	2.4014 mL	12.0071 mL
50 mM	0.0961 mL	0.4803 mL	0.9606 mL	4.8028 mL
100 mM	0.0480 mL	0.2401 mL	0.4803 mL	2.4014 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc