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Anti-LGR-5 Antibody (8V603)
😃Good
Catalog No. TMAH-00695
Alias LGR5, HG38, G-protein coupled receptor HG38, G-protein coupled receptor 67, G-protein coupled receptor 49, GPR67, GPR49
Anti-LGR-5 Antibody (8V603) is an antibody targeting LGR-5. Anti-LGR-5 Antibody (8V603) can be used in ELISA, WB, FC.
Anti-LGR-5 Antibody (8V603)
Anti-LGR-5 Antibody (8V603)
😃Good
Catalog No. TMAH-00695Alias LGR5, HG38, G-protein coupled receptor HG38, G-protein coupled receptor 67, G-protein coupled receptor 49, GPR67, GPR49
Anti-LGR-5 Antibody (8V603) is an antibody targeting LGR-5. Anti-LGR-5 Antibody (8V603) can be used in ELISA, WB, FC.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $209 | 7-10 days | |
| 100 μL | $347 | 7-10 days |
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Antigen Details
Chemical Properties
| Description | Anti-LGR-5 Antibody (8V603) is an antibody targeting LGR-5. Anti-LGR-5 Antibody (8V603) can be used in ELISA, WB, FC. |
| Alias | LGR5, HG38, G-protein coupled receptor HG38, G-protein coupled receptor 67, G-protein coupled receptor 49, GPR67, GPR49 |
| Ig Type | Rabbit IgG |
| Clone | 8V603 |
| Reactivity | Human, Rat |
| Verified Activity | 1. Western Blot -Positive WB detected in: SH-SY5Y whole cell lysate, Rat brain tissue -All lanes: LGR5 antibody at 1:1500 -Secondary: Goat polyclonal to rabbit IgG at 1/50000 dilution -Predicted band size: 100, 98, 93 kDa -Observed band size: 100 kDa 2. Overlay histogram showing HepG2 cells stained with TMAH-00695 (red line) at 1:50. The cells were fixed in 4% formaldehyde (15min) and permeated by 0.2% TritonX-100 for 10min. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*10^6 cells) for 45min at 4°C.The secondary antibody used was FITC-conjugated goat anti-rabbit IgG (H+L) at 1/200 dilution for 30min at 4°C. Control antibody (green line) was Rabbit IgG (1µg/1*10^6 cells) used under the same conditions. Acquisition of >10,000 events was performed. |
| Application | ELISA, WB, FC |
| Recommended Dose | WB:1:500-1:5000; FC:1:20-1:200. |
| Antibody Type | Monoclonal |
| Subcellular Localization | Cell membrane; Multi-pass membrane protein. Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. |
| Construction | Recombinant Antibody |
| Purification | Affinity-chromatography |
| Appearance | Liquid |
| Formulation | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Research Background | Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development. |
| Conjucates | Unconjugated |
| Immunogen | A synthetic peptide: Human LGR5/GPR49 |
| Antigen Species | Human |
| Gene ID | 8549 |
| Uniprot ID | |
| Biology Area | Cancer, Signal transduction, Stem cells |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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