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Anti-Phospho-Shc (Tyr427) Polyclonal Antibody
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Catalog No. TMAC-03738
Anti-Phospho-Shc (Tyr427) Polyclonal Antibody is a Rabbit antibody targeting Phospho-Shc (Tyr427). Anti-Phospho-Shc (Tyr427) Polyclonal Antibody can be used in WB,IHC,IF.
Anti-Phospho-Shc (Tyr427) Polyclonal Antibody
Anti-Phospho-Shc (Tyr427) Polyclonal Antibody
😃Good
Catalog No. TMAC-03738
Anti-Phospho-Shc (Tyr427) Polyclonal Antibody is a Rabbit antibody targeting Phospho-Shc (Tyr427). Anti-Phospho-Shc (Tyr427) Polyclonal Antibody can be used in WB,IHC,IF.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $218 | 7-10 days | |
| 100 μL | $317 | 7-10 days |
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| Description | Anti-Phospho-Shc (Tyr427) Polyclonal Antibody is a Rabbit antibody targeting Phospho-Shc (Tyr427). Anti-Phospho-Shc (Tyr427) Polyclonal Antibody can be used in WB,IHC,IF. |
| Ig Type | IgG |
| Reactivity | Human |
| Application | |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Construction | Polyclonal Antibody |
| Purification | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. |
| Appearance | Liquid |
| Formulation | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Research Background | Signaling adapter that couples activated growth factor receptors to signaling pathway. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span |
| Conjucates | Unconjugated |
| Others Formats | Phospho |
| Immunogen | Peptide sequence around phosphorylation site of tyrosine 427 (P-S-Y(p)-V-N derived from Human Shc1 |
| Antigen Species | human |
| Uniprot ID |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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