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Gastrodin

Name: Gastrodin
Brand: TargetMol
SKU: T2999
Price: 44 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T2999Cas No. 62499-27-8

Alias Gastrodine

Gastrodin (Gastrodine), an anti-inflammatory polyphenol, is extracted from Chinese natural herbal Gastrodia elata Blume. and benefits neurodegenerative diseases.

Gastrodin

🥰Excellent

Purity: 99.87%

Catalog No. T2999Alias GastrodineCas No. 62499-27-8

Gastrodin (Gastrodine), an anti-inflammatory polyphenol, is extracted from Chinese natural herbal Gastrodia elata Blume. and benefits neurodegenerative diseases.

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$44	In Stock	In Stock
100 mg	$70	In Stock	In Stock
500 mg	$163	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.87%

Appearance:Solid

Color:White

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COA HNMR HPLC LCMS

Product Introduction

Bioactivity

Description	Gastrodin (Gastrodine), an anti-inflammatory polyphenol, is extracted from Chinese natural herbal Gastrodia elata Blume. and benefits neurodegenerative diseases.
In vitro	In mice, the LD50 of Gastrodin is greater than 1000 mg/kg (i.v.). In rats, Gastrodin at a dose of 5 mg/kg is effective in alleviating memory deficits induced by cycloheximide and apomorphine but is ineffective against scopolamine-induced acquisition impairments. Therefore, Gastrodin enhances memory consolidation and retrieval but does not facilitate memory acquisition.
In vivo	In microglial cells stimulated by lipopolysaccharide, Gastrodin at concentrations of 30, 40, and 60 mM inhibits the NF-κB signaling pathway and phosphorylation of MAPKs, significantly reducing the levels of neurotoxic inflammatory mediators and cytokines. Furthermore, in H9c2 cardiomyocytes, Gastrodin upregulates the PI3-K/Akt signaling pathway, consequently inhibiting the activation of NF-κB and MAPKs.
Synonyms	Gastrodine

Chemical Properties

Molecular Weight	286.28
Formula	C₁₃H₁₈O₇
Cas No.	62499-27-8
Smiles	O([C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C2=CC=C(CO)C=C2
Relative Density.	1.504 g/cm3 (Predicted)

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 252.5 mg/mL (882 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.99 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.4931 mL	17.4654 mL	34.9308 mL	174.6542 mL
5 mM	0.6986 mL	3.4931 mL	6.9862 mL	34.9308 mL
10 mM	0.3493 mL	1.7465 mL	3.4931 mL	17.4654 mL
20 mM	0.1747 mL	0.8733 mL	1.7465 mL	8.7327 mL
50 mM	0.0699 mL	0.3493 mL	0.6986 mL	3.4931 mL
100 mM	0.0349 mL	0.1747 mL	0.3493 mL	1.7465 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc