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Tetrahydropalmatine
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Catalog No. T2793Cas No. 6024-85-7
Alias Rotundine, DL-Tetrahydropalmatine
Tetrahydropalmatine (DL-Tetrahydropalmatine) is an active component isolated from corydalis, suppressing amygdaloid release of dopamine to inhibit an epileptic attack in rats.
Tetrahydropalmatine
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Purity: 99.95%
Catalog No. T2793Alias Rotundine, DL-TetrahydropalmatineCas No. 6024-85-7
Tetrahydropalmatine (DL-Tetrahydropalmatine) is an active component isolated from corydalis, suppressing amygdaloid release of dopamine to inhibit an epileptic attack in rats.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | $41 | In Stock | In Stock | |
| 50 mg | $89 | In Stock | In Stock | |
| 100 mg | $134 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $45 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.95%
Appearance:Solid
Color:White
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Product Introduction
Tetrahydropalmatine AI Summary
Tetrahydropalmatine exhibits a high affinity for sigma receptor type 1 in guinea pig assays, with a Ki value of 2.5 nM, indicating potential sigma receptor modulation bioactivity. It displays diverse bioactivities including both activating and inhibitory effects on Cytochrome P450 3A4, inhibition of human tyrosyl-DNA phosphodiesterase 1 (TDP1) in different cellular conditions, and inhibitory action against Plasmodium falciparum (DD2) proliferation. The compound also inhibits the tissue factor procoagulant activity in LPS-stimulated human THP1 cells, with an IC50 value of 14.98 nM after 5 hours of preincubation. Moreover, Tetrahydropalmatine shows moderate to weak antiviral activity against SARS-CoV-2, with an IC50 value greater than 19952.62 nM in VERO-6 cells..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Tetrahydropalmatine (DL-Tetrahydropalmatine) is an active component isolated from corydalis, suppressing amygdaloid release of dopamine to inhibit an epileptic attack in rats. |
| Synonyms | Rotundine, DL-Tetrahydropalmatine |
| Molecular Weight | 355.43 |
| Formula | C21H25NO4 |
| Cas No. | 6024-85-7 |
| Smiles | Cl.COc1cc2CCN3Cc4c(CC3c2cc1OC)ccc(OC)c4OC |
| Relative Density. | 1.23g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 16.7 mg/mL (46.99 mM), Sonication is recommended.  | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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