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Anti-3-Nitro-L-tyrosine Polyclonal Antibody
(Synonyms: nTyr, NO tyrosine, nitro-Tyrosine, Nitrotyrosine, 3-Nitrotyrosine) Copy Product Info
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Synonyms: nTyr, NO tyrosine, nitro-Tyrosine, Nitrotyrosine, 3-Nitrotyrosine
Catalog No. TMAB-00003 Copy Product Info
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Anti-3-Nitro-L-tyrosine Polyclonal Antibody is a Rabbit antibody targeting 3-Nitro-L-tyrosine. Anti-3-Nitro-L-tyrosine Polyclonal Antibody can be used in FCM, IF, IHC-Fr, IHC-P, WB.
Anti-3-Nitro-L-tyrosine Polyclonal Antibody
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $221 | 7-10 days | 7-10 days | |
| 100 μL | $374 | 7-10 days | 7-10 days | |
| 200 μL | $528 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
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| Description | Anti-3-Nitro-L-tyrosine Polyclonal Antibody is a Rabbit antibody targeting 3-Nitro-L-tyrosine. Anti-3-Nitro-L-tyrosine Polyclonal Antibody can be used in FCM, IF, IHC-Fr, IHC-P, WB. |
| Synonyms | nTyr, NO tyrosine, nitro-Tyrosine, Nitrotyrosine, 3-Nitrotyrosine |
| Ig Type | IgG |
| Reactivity | Species independent |
| Application | |
| Recommended Dose | FCM=1 μg/Test; IF=1:100-500; IHC-Fr=1:100-500; IHC-P=1:100-500; WB=1:500-2000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cytoplasm. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1 mg/mL |
| Research Background | Nitrotyrosine is a marker for inflammation and nitric oxide (NO) production and is formed in the presence of the active metabolite NO. Because nitrotyrosine is a stable product of multiple pathways, such as the formation of peroxynitrite, its plasma concentration may be a useful determinant of NO-dependent damage in vivo. Nitrotyrosine has been detected in inflammatory processes such as septic shock, rheumatoid arthritis, celiac disease, atherosclerotic plaques and chronic renal failure. Protein tyrosine nitration results in a post-translational modification that is increasingly receiving attention as an important component of nitric oxide signaling. While multiple nonenzymatic mechanisms are known to be capable of producing nitrated tyrosine residues, most tyrosine nitration events involve catalysis by metalloproteins such as myeloperoxidase, eosinophilperoxidase, myoglobin, the cytochrome P-450s, superoxide dismutase and prostacyclin synthase. Various studies have shown that protein tyrosinenitration is limited to specific proteins and that the process is selective. For example, exposure of human surfactant protein A, SP-A, to oxygen-nitrogen intermediates generated by activated alveolar macrophages resulted in specific nitration of SP-A at tyrosines 164 and 166, while addition of 1.2 mMCO 2 resulted in additional nitration at tyrosine 161. The presence of nitrotyrosine-containing proteins has shown high correlation to disease states such as atherosclerosis, Alzheimer’s disease, Parkinson’s disease and amyotrophic lateral sclerosis. |
| Immunogen | KLH conjugated Nitrotyrosine |
| Biology Area | Signal transduction proteins ELISA kits,Amino Acids |
| Molecular Weight | Actual: 73 kDa. |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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