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Anti-Phospho-HDAC3 (Ser424) Polyclonal Antibody 2
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Catalog No. TMAB-10769
Anti-Phospho-HDAC3 (Ser424) Polyclonal Antibody 2 is a Rabbit antibody targeting Phospho-HDAC3 (Ser424). Anti-Phospho-HDAC3 (Ser424) Polyclonal Antibody 2 can be used in WB,IHC-P,IHC-Fr,IF,FCM.
Anti-Phospho-HDAC3 (Ser424) Polyclonal Antibody 2
Anti-Phospho-HDAC3 (Ser424) Polyclonal Antibody 2
😃Good
Catalog No. TMAB-10769
Anti-Phospho-HDAC3 (Ser424) Polyclonal Antibody 2 is a Rabbit antibody targeting Phospho-HDAC3 (Ser424). Anti-Phospho-HDAC3 (Ser424) Polyclonal Antibody 2 can be used in WB,IHC-P,IHC-Fr,IF,FCM.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $221 | 7-10 days | 7-10 days | |
| 100 μL | $373 | 7-10 days | 7-10 days | |
| 200 μL | $527 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-Phospho-HDAC3 (Ser424) Polyclonal Antibody 2 is a Rabbit antibody targeting Phospho-HDAC3 (Ser424). Anti-Phospho-HDAC3 (Ser424) Polyclonal Antibody 2 can be used in WB,IHC-P,IHC-Fr,IF,FCM. |
| Ig Type | IgG |
| Reactivity | Human,Mouse,Rat |
| Application | |
| Recommended Dose | WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500; FCM: 1μg/Test |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Nucleus. |
| Tissue Specificity | Widely expressed. |
| Construction | Hybridoma Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene. [provided by RefSeq, Jul 2008] |
| Immunogen | KLH conjugated Synthesised phosphopeptide: human HDAC3 around the phosphorylation site of Ser424 |
| Antigen Species | Human |
| Gene Name | HDAC3 |
| Gene ID | |
| Protein Name | Histone deacetylase 3 |
| Uniprot ID | |
| Function | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation. |
| Molecular Weight | Theoretical: 47 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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