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ML-226

Name: ML-226
Brand: TargetMol
SKU: T8994
Price: 143 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T8994Cas No. 2055172-43-3

Alias ML-226, ML226

ML226 is a α/β hydrolase domain-containing protein 11 (ABHD11) inhibitor that inhibits ABHD11 in vitro and in situ.

ML-226

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Purity: 99.61%

Catalog No. T8994Alias ML-226, ML226Cas No. 2055172-43-3

ML226 is a α/β hydrolase domain-containing protein 11 (ABHD11) inhibitor that inhibits ABHD11 in vitro and in situ.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$143	-	In Stock
5 mg	$438	-	In Stock
10 mg	$689	-	In Stock
1 mL x 10 mM (in DMSO)	$482	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.61%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

ML-226 AI Summary

ML-226 exhibits bioactivity as an inhibitor of LYPLA1, LYPLA2, and ABHD11, with potent inhibitory effects against ABHD11 (IC50 = 0.678 nM and 15.0 nM) as demonstrated in gel-based Activity-Based Protein Profiling (ABPP) assays. The compound shows minimal or no inhibition against human APT2 and APT1 (IC50 values >10,000.0 nM). Additionally, ML-226 inhibits both recombinant mouse DAGLbeta and full-length recombinant human DAGLalpha enzymes expressed in HEK293T cell membranes, displaying much higher potency for human DAGLalpha (IC50 = 63.1 nM) compared to mouse DAGLbeta (IC50 = 12589.25 nM)..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	ML226 is a α/β hydrolase domain-containing protein 11 (ABHD11) inhibitor that inhibits ABHD11 in vitro and in situ.
Synonyms	ML-226, ML226

Chemical Properties

Molecular Weight	390.48
Formula	C₂₃H₂₆N₄O₂
Cas No.	2055172-43-3
Smiles	C(O)(C1=NN(C(=O)N2C(CC)CCCC2)N=C1)(C3=CC=CC=C3)C4=CC=CC=C4
Relative Density.	1.22 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 25 mg/mL (64.02 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5610 mL	12.8048 mL	25.6095 mL	128.0475 mL
5 mM	0.5122 mL	2.5610 mL	5.1219 mL	25.6095 mL
10 mM	0.2561 mL	1.2805 mL	2.5610 mL	12.8048 mL
20 mM	0.1280 mL	0.6402 mL	1.2805 mL	6.4024 mL
50 mM	0.0512 mL	0.2561 mL	0.5122 mL	2.5610 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc