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Fluocinolone (Acetonide)

Name: Fluocinolone (Acetonide)
Brand: TargetMol
SKU: T0367
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0367Cas No. 67-73-2

Alias Fluocinolone acetonide, Flucort-N

Fluocinolone Acetonide (Flucort-N) is a glucocorticoid derivative used topically in the treatment of various skin disorders. It is usually employed as a cream, gel, lotion, or ointment. It has also been used topically in the treatment of inflammatory eye, ear, and nose disorders.

Fluocinolone (Acetonide)

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Purity: 99.82%

Catalog No. T0367Alias Fluocinolone acetonide, Flucort-NCas No. 67-73-2

Pack Size	Price	USA Warehouse	Global Warehouse
500 mg	$35	In Stock	In Stock
1 g	$58	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.82%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Fluocinolone (Acetonide) AI Summary

Fluocinolone (Acetonide) demonstrates strong vasoconstrictor activity in humans and exhibits potent topical anti-inflammatory and systemic corticosteroid activities in mice and rats, outperforming fluocinolone acetonide in similar assays. It has a significant binding affinity to beta-cyclodextrin, with a log Ks value of 3.48, and high bioactivity in glucocorticoid radioligand binding assays (IC50 of 3.131 nM, Ki of 1.423 nM). Moderate potency is noted in progesterone radioligand binding assays, with an IC50 of 26.0 nM and Ki of 3.346 nM. It exhibits moderate inhibitory activity against cell viability in SARS-CoV-2 infected Vero E6 cells and inhibits the SARS-CoV-2 3CL-Pro protease by 11.26% at 20µM. Additionally, it shows diverse bioactivity, including inhibition of ERK signaling, induction of synthetic lethality in tumor cells producing 2HG, and miR-21 activation with notable potency (46.5 nM). The compound effectively inhibits Polymeras Iota and possesses varying degrees of antimicrobial activity against fungi and bacteria. However, it exhibits no liver-related side effects based on DILIps training set data, although it does affect various biomarkers indicating potential hepatotoxic, nephrotoxic, metabolic, and hematological effects..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Fluocinolone Acetonide (Flucort-N) is a glucocorticoid derivative used topically in the treatment of various skin disorders. It is usually employed as a cream, gel, lotion, or ointment. It has also been used topically in the treatment of inflammatory eye, ear, and nose disorders.
Targets&IC50	GR:2.0 nM
Synonyms	Fluocinolone acetonide, Flucort-N

Chemical Properties

Molecular Weight	452.49
Formula	C₂₄H₃₀F₂O₆
Cas No.	67-73-2
Smiles	[H][C@@]12C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])C[C@H](F)C2=CC(=O)C=C[C@]12C
Relative Density.	1.36g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 10 mg/mL (22.1 mM), Sonication is recommended.

DMSO: 83 mg/mL (183.43 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (7.29 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2100 mL	11.0500 mL	22.0999 mL	110.4997 mL
5 mM	0.4420 mL	2.2100 mL	4.4200 mL	22.0999 mL
10 mM	0.2210 mL	1.1050 mL	2.2100 mL	11.0500 mL
20 mM	0.1105 mL	0.5525 mL	1.1050 mL	5.5250 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0442 mL	0.2210 mL	0.4420 mL	2.2100 mL
100 mM	0.0221 mL	0.1105 mL	0.2210 mL	1.1050 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc