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Isosakuranetin

Name: Isosakuranetin
Brand: TargetMol
SKU: T5S0229
Price: 44 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5S0229Cas No. 480-43-3

Alias 4'-Methylnaringenin

1. Isosakuranetin (4'-Methylnaringenin) has cytotoxic and fungicide properties. 2. Isosakuranetin produces significant decrease in blood pressure. 3. Isosakuranetin significantly reduces the sensitivity of mice to noxious heat and PregS-induced chemical pain.

Isosakuranetin

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Purity: 99.82%

Catalog No. T5S0229Alias 4'-MethylnaringeninCas No. 480-43-3

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$44	In Stock	In Stock
5 mg	$97	In Stock	In Stock
10 mg	$139	In Stock	In Stock
25 mg	$233	In Stock	In Stock
50 mg	$345	In Stock	In Stock
100 mg	$512	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$146	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.82%

Appearance:Solid

Color:White to Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Isosakuranetin AI Summary

Isosakuranetin exhibits a range of bioactivities across different biological systems and assays. It has shown to inhibit cow milk xanthine oxidase activity at 50 µg/mL, despite a recorded inhibition of 0.0%. The compound demonstrates cytotoxicity against rat H4IIE cells with an IC50 value greater than 100,000.0 nM, indicating low potency. It also inhibits metabolism of [3H]benzo(a)pyrene in Syrian hamster embryo cells, with inhibition percentages of -63.0%, -28.0%, and -11.0% at concentrations of 20 µg/mL, 10 µg/mL, and 5 µg/mL, respectively. For antifungal properties, it inhibits Cladosporium cladosporioides and Cladosporium sphaerospermum with minimum inhibitory concentrations of 1.0 µg and 5.0 µg, respectively. In terms of cytochrome P450 inhibition, Isosakuranetin has IC50 values of 1024.0 nM for CYP1B1, 2196.0 nM for CYP1A1, and 3147.0 nM for CYP1A2. It counteracts IL1-induced tissue factor expression in human monocytes with no significant activity at 10 µM. Additionally, it serves as an inhibitor of ROR gamma (IC50 = 12589.3 nM), a competitive binder for novel anesthetics (IC50 = 22387.2 nM), and blocks Marburg Virus entry (IC50 = 14125.4 nM). It shows cytotoxic activity against human HCT116 cells and exhibits antiangiogenic activity in embryonated chicken eggs (38.1% inhibition at 300 ng/CAM). Isosakuranetin also inhibits SARS-CoV-2 3CL-Pro protease by 9.28% at 20 µM and shows antiviral activity in VERO-6 cells against SARS-CoV-2 with a 0.33% inhibition rate at 10 µM. Lastly, it inhibits electric eel acetylcholinesterase by 20.97% at 2 mg/mL, but does not significantly inhibit horse butyrylcholinesterase, which exhibited an inhibition of -3.1% at the same concentration..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	1. Isosakuranetin (4'-Methylnaringenin) has cytotoxic and fungicide properties. 2. Isosakuranetin produces significant decrease in blood pressure. 3. Isosakuranetin significantly reduces the sensitivity of mice to noxious heat and PregS-induced chemical pain.
Synonyms	4'-Methylnaringenin

Chemical Properties

Molecular Weight	286.28
Formula	C₁₆H₁₄O₅
Cas No.	480-43-3
Smiles	COc1ccc(cc1)[C@@H]1CC(=O)c2c(O)cc(O)cc2O1
Relative Density.	1.37g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (873.27 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.99 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.4931 mL	17.4654 mL	34.9308 mL	174.6542 mL
5 mM	0.6986 mL	3.4931 mL	6.9862 mL	34.9308 mL
10 mM	0.3493 mL	1.7465 mL	3.4931 mL	17.4654 mL
20 mM	0.1747 mL	0.8733 mL	1.7465 mL	8.7327 mL
50 mM	0.0699 mL	0.3493 mL	0.6986 mL	3.4931 mL
100 mM	0.0349 mL	0.1747 mL	0.3493 mL	1.7465 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc