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Cimetidine

🥰Excellent
Catalog No. T0797Cas No. 51481-61-9
Alias SKF-92334

Cimetidine (SKF-92334) is a histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.

Cimetidine
Other Forms of Cimetidine:
Cimetidine hydrochlorideT6058470059-30-2
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Cimetidine

🥰Excellent
Purity: 99.82%
Catalog No. T0797Alias SKF-92334Cas No. 51481-61-9
Cimetidine (SKF-92334) is a histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 g$54In StockIn Stock
1 mL x 10 mM (in DMSO)$50In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.82%
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COA HNMR LCMS

Product Introduction

Bioactivity
Description
Cimetidine (SKF-92334) is a histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
Targets&IC50
Histamine receptor:0.6 μM (Ki)
SynonymsSKF-92334
Chemical Properties
Molecular Weight252.34
FormulaC10H16N6S
Cas No.51481-61-9
SmilesCN\C(NCCSCC1=C(C)NC=N1)=N/C#N
Relative Density.1.2583 g/cm3 (Estimated)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
H2O: < 1 mg/mL (insoluble or slightly soluble)
Ethanol: 3 mg/mL (11.89 mM), Sonication is recommended.
DMSO: 45 mg/mL (178.33 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2.5 mg/mL (9.91 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
Ethanol/DMSO
1mg5mg10mg50mg
1 mM3.9629 mL19.8145 mL39.6291 mL198.1454 mL
5 mM0.7926 mL3.9629 mL7.9258 mL39.6291 mL
10 mM0.3963 mL1.9815 mL3.9629 mL19.8145 mL
DMSO
1mg5mg10mg50mg
20 mM0.1981 mL0.9907 mL1.9815 mL9.9073 mL
50 mM0.0793 mL0.3963 mL0.7926 mL3.9629 mL
100 mM0.0396 mL0.1981 mL0.3963 mL1.9815 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
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% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

SKF92334SKF 92334inverseInhibitorinhibitHistamineReceptorHistamine ReceptorH2 receptorCimetidineanti-inflammatoryanti-cancer
Related Tags: buy Cimetidine | purchase Cimetidine | Cimetidine cost | order Cimetidine | Cimetidine chemical structure | Cimetidine formula | Cimetidine molecular weight
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