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Fipexide
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Catalog No. T0322Cas No. 34161-24-5
Fipexide (Attentil, Vigilor), a psychoactive drug of the piperazine chemical class, was developed in Italy in 1983. It was served as a nootropic drug in France and Italy, mainly for the therapy of senile dementia, but is no longer in common use because of the occurrence of rare drug side-effects including hepatitis and fever.
Fipexide
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Purity: 99.95%
Catalog No. T0322Cas No. 34161-24-5
Fipexide (Attentil, Vigilor), a psychoactive drug of the piperazine chemical class, was developed in Italy in 1983. It was served as a nootropic drug in France and Italy, mainly for the therapy of senile dementia, but is no longer in common use because of the occurrence of rare drug side-effects including hepatitis and fever.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 mg | $31 | - | In Stock | |
| 50 mg | $41 | - | In Stock | |
| 100 mg | $50 | - | In Stock | |
| 200 mg | $75 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $50 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.95%
Appearance:Solid
Color:White to Yellow
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Product Introduction
Fipexide AI Summary
Fipexide exhibits a wide range of bioactivities, including significant inhibition of acid sphingomyelinase (ASM) in human H4 cells, displaying an activity level of 121.3% at a concentration of 10 µM. This compound also shows potency across various biological assays, modulating Lamin A splicing, inhibiting mitochondrial division, and acting as both an agonist and antagonist in hypoxia response signaling pathways. It affects multiple Cytochrome P450 enzymes, showing interactions with enzymes like CYP2C19, CYP2D6, and CYP3A4, as well as human Hep3B cells where it induces cytotoxicity via these enzymes.
In antiviral research, Fipexide has been observed to inhibit SARS-CoV-2-induced cytotoxicity of VERO-6 cells, albeit with a relatively weak IC50 value of greater than 20,000 nM. Additionally, it shows negligible inhibition of human HDAC6 enzyme activity.
In terms of receptor interactions, Fipexide binds various receptors, including DRD1, SLC6A3, SLC6A2, SLC6A4, ADRA2A, OPRM1, DRD3, CHRM2, HTR1A, TBXA2R, ADORA3, HRH3, GABRA1, AR, and PGR. It also demonstrates antagonist activity at TBXA2R and CHRM1, and influences channels and enzymes such as KCNH2, ABCB11, MAOA, F2, KDR, PDE3A, SCN5A, PTGS1, and PDE4A with varying potency levels.
Regarding safety, Fipexide presents moderate to severe liver toxicity. Clinical-chemistry results reveal significant elevations in ALT and AST levels, and it triggers acute forms of liver toxicity such as cytolytic hepatitis, though it appears less active in causing chronic liver diseases or tumors. It scores highly on Drug Induced Liver Injury (DILI) prediction systems and exhibits a liver toxicity severity index of 8.0.
Overall, Fipexide showcases diverse pharmacological interactions and significant bioactivities, yet its therapeutic potential is offset by notable hepatotoxic risks..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Fipexide (Attentil, Vigilor), a psychoactive drug of the piperazine chemical class, was developed in Italy in 1983. It was served as a nootropic drug in France and Italy, mainly for the therapy of senile dementia, but is no longer in common use because of the occurrence of rare drug side-effects including hepatitis and fever. |
| Molecular Weight | 388.84 |
| Formula | C20H21ClN2O4 |
| Cas No. | 34161-24-5 |
| Smiles | Clc1ccc(OCC(=O)N2CCN(Cc3ccc4OCOc4c3)CC2)cc1 |
| Relative Density. | 1.342g/cm3 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 55 mg/mL (141.45 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.14 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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