Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Voxvoganan (LTX-109) trihydrochloride, a topical antimicrobial, demonstrates a high efficacy against S. aureus, exhibiting a MIC range of 2 to 4 μg/mL. It is utilized in research for treating bacterial skin infections, fungal infections, and nasal decolonization of MRSA [1] [2].
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Description | Voxvoganan (LTX-109) trihydrochloride, a topical antimicrobial, demonstrates a high efficacy against S. aureus, exhibiting a MIC range of 2 to 4 μg/mL. It is utilized in research for treating bacterial skin infections, fungal infections, and nasal decolonization of MRSA [1] [2]. |
In vitro | Voxvoganan trihydrochloride (LTX-109) is a chemically synthesized, first-in-class antimicrobial agent employing a membrane-lysing mechanism akin to innate immune effector lytic peptides. It exhibits rapid, broad-spectrum bactericidal effects, efficiently targeting the cell walls of various S. aureus strains, including those resistant to multiple antimicrobial classes [2]. Clinically, its topical application is characterized by a favorable safety profile, minimal bioavailability, and effective action against both mupirocin-susceptible and -resistant Staphylococcus aureus [3]. |
Synonyms | LTX-109 trihydrochloride |
Molecular Weight | 897.46 |
Formula | C43H72Cl3N11O3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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