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Anti-ABCG2 Polyclonal Antibody
(Synonyms: UAQTL1, Placenta specific MDR protein, Placenta specific ATP binding cassette transporter, MXR1, MXR, Multi drug resistance efflux transport ATP binding cassette sub family G(WHITE) member 2, MRX, Mitoxantrone resistance associated protein, MGC102821, GOUT1, EST157481, CDw338 antigen, CDw338, CD338, Breast cancer resistance protein, BMDP, BCRP1, ATP-binding cassette sub-family G member 2, ATP binding cassette transporter G2, ATP binding cassette sub family G(WHITE) member 2, ABCP, ABCG 2, ABC15) Copy Product Info
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Synonyms: UAQTL1, Placenta specific MDR protein, Placenta specific ATP binding cassette transporter, MXR1, MXR, Multi drug resistance efflux transport ATP binding cassette sub family G(WHITE) member 2, MRX, Mitoxantrone resistance associated protein, MGC102821, GOUT1, EST157481, CDw338 antigen, CDw338, CD338, Breast cancer resistance protein, BMDP, BCRP1, ATP-binding cassette sub-family G member 2, ATP binding cassette transporter G2, ATP binding cassette sub family G(WHITE) member 2, ABCP, ABCG 2, ABC15
Catalog No. TMAB-00024 Copy Product Info
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Anti-ABCG2 Polyclonal Antibody is a Rabbit antibody targeting ABCG2. Anti-ABCG2 Polyclonal Antibody can be used in ELISA,IF,IHC-Fr,IHC-P,WB.
Anti-ABCG2 Polyclonal Antibody
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $221 | 7-10 days | 7-10 days | |
| 100 μL | $372 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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| Description | Anti-ABCG2 Polyclonal Antibody is a Rabbit antibody targeting ABCG2. Anti-ABCG2 Polyclonal Antibody can be used in ELISA,IF,IHC-Fr,IHC-P,WB. |
| Synonyms | UAQTL1, Placenta specific MDR protein, Placenta specific ATP binding cassette transporter, MXR1, MXR, Multi drug resistance efflux transport ATP binding cassette sub family G(WHITE) member 2, MRX, Mitoxantrone resistance associated protein, MGC102821, GOUT1, EST157481, CDw338 antigen, CDw338, CD338, Breast cancer resistance protein, BMDP, BCRP1, ATP-binding cassette sub-family G member 2, ATP binding cassette transporter G2, ATP binding cassette sub family G(WHITE) member 2, ABCP, ABCG 2, ABC15 |
| Ig Type | IgG |
| Reactivity | Human,Mouse,Rat |
| Application | |
| Recommended Dose | WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500; ELISA: 1:5000-10000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cell membrane; Multi-pass membrane protein. |
| Tissue Specificity | Highly expressed in placenta. Low expression in small intestine, liver and colon. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1 mg/mL |
| Research Background | An ABC transporter. Allows efflux of Hoechst dye, a property that has been used to separate bone marrow side population cells, which express BCRP/ABCG2. Appears to play a major role in the multidrug resistance phenotype of a specific MCF-7 breast cancer cell line. When overexpressed, the transfected cells become resistant to mitoxantrone, daunorubicin and doxorubicin, display diminished intracellular accumulation of daunorubicin, and manifest an ATP-dependent increase in the efflux of rhodamine 123. Breast Cancer Resistance Protein (BCRP) is a 70 kDa ATP-Binding Cassette membrane transport protein involved in multidrug resistance. BCRP may be over-expressed in cancer cell lines selected with doxorubicin / verapamil, topotecan or mitoxantrone. |
| Immunogen | KLH conjugated synthetic peptide: human ABCG2 |
| Antigen Species | Human |
| Gene Name | ABCG2 |
| Gene ID | |
| Protein Name | Broad substrate specificity ATP-binding cassette transporter ABCG2 |
| Uniprot ID | |
| Biology Area | MRP-related proteins,Drug metabolism,Drug metabolism,ATPases,Surface Molecules,Surface Molecules,Tumor Associated |
| Function | Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. May be involved in brain-to-blood efflux. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. When overexpressed, the transfected cells become resistant to mitoxantrone, daunorubicin and doxorubicin, display diminished intracellular accumulation of daunorubicin, and manifest an ATP-dependent increase in the efflux of rhodamine 123. |
| Molecular Weight | Theoretical: 72 kDa. Actual: 82 kDa. |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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