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Anti-Her2/ERBB2 Antibody (6Y940)
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Catalog No. TMAY-00034
Alias erb-b2 receptor tyrosine kinase 2, EGFR2
Anti-Her2/ERBB2 Antibody (6Y940) is a Mouse antibody targeting Her2/ERBB2. Anti-Her2/ERBB2 Antibody (6Y940) can be used in FCM,ICC/IF.
Anti-Her2/ERBB2 Antibody (6Y940)
Anti-Her2/ERBB2 Antibody (6Y940)
😃Good
Catalog No. TMAY-00034Alias erb-b2 receptor tyrosine kinase 2, EGFR2
Anti-Her2/ERBB2 Antibody (6Y940) is a Mouse antibody targeting Her2/ERBB2. Anti-Her2/ERBB2 Antibody (6Y940) can be used in FCM,ICC/IF.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 20 μL | $68 | 7-10 days | |
| 100 μL | $198 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Mouse Monoclonal Application: FCM, ICC/IF Reactivity: Human |
| Alias | erb-b2 receptor tyrosine kinase 2, EGFR2 |
| Ig Type | Mouse IgG1 |
| Clone | 6Y940 |
| Reactivity | Human |
| Verified Activity | 1. Immunofluorescence staining of Human ERBB2 in MCF7 cells. Cells were fixed with 4% PFA, blocked with 10% serum, and incubated with mouse anti-Human ERBB2 monoclonal antibody (1:60) at 4°C overnight. Then cells were stained with the Alexa Fluor® 488-conjugated Goat Anti-mouse IgG secondary antibody(green). Positive staining was localized to cell membrane. 2. Flow cytometric analysis of anti-Human ErbB2 on MCF-7 cells. |
| Application | FCM,ICC/IF |
| Recommended Dose | ICC-IF: 1:20-1:100; FCM: 1:25-1:100 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human HER2 / ErbB2 (rh HER2 / ErbB2; TMPY-01137; NP_004439.2; Met1-Thr652). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS with 10% Trehalose, pH7.0 |
| Research Background | Human epidermal growth factor receptor 2 (HER2), also known as ErbB2, NEU, and CD340, is a type I membrane glycoprotein and belongs to the epidermal growth factor (EGF) receptor family. HER2 protein cannot bind growth factors due to the lacking of ligand binding domain of its own and autoinhibited constitutively. However, HER2 forms a heterodimer with other ligand-bound EGF receptor family members, therefore stabilizes ligand binding and enhances kinase-mediated activation of downstream molecules. HER2 plays a key role in development, cell proliferation and differentiation. HER2 gene has been reported to associate with malignancy and a poor prognosis in numerous carcinomas, including breast, prostate, ovarian, lung cancers and so on.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| Conjucates | Unconjugated |
| Others Formats | APC/FITC/PE |
| Antibody Types Available | 4 |
| Immunogen | Recombinant Protein: Human HER2 / ErbB2 protein (TMPY-01137) |
| Antigen Species | Human |
| Biology Area | Cancer Drug Targets, Receptor Tyrosine Kinases (RTKs) |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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