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Anti-Phospho-Shc (Tyr349) Polyclonal Antibody (Synonyms: Shc (p-Y349), Shc (p-Tyr349), p-Shc (Y349), p-Shc (T...)
Catalog No. TMAC-03737 Copy Product Info
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Anti-Phospho-Shc (Tyr349) Polyclonal Antibody is a Rabbit antibody targeting Phospho-Shc (Tyr349). Anti-Phospho-Shc (Tyr349) Polyclonal Antibody can be used in IF,WB.
Anti-Phospho-Shc (Tyr349) Polyclonal Antibody
Copy Product Info🥰Excellent
Catalog No. TMAC-03737
Synonyms Shc (p-Y349), Shc (p-Tyr349), p-Shc (Y349), p-Shc (Tyr349)
Anti-Phospho-Shc (Tyr349) Polyclonal Antibody is a Rabbit antibody targeting Phospho-Shc (Tyr349). Anti-Phospho-Shc (Tyr349) Polyclonal Antibody can be used in IF,WB.
Anti-Phospho-Shc
(Tyr349) Polyclonal Antibody
(Tyr349) Polyclonal Antibody
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $216 | 7-10 days | 7-10 days | |
| 100 μL | $317 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Bioactivity
Related Conjugates and Formulations
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Chemical Properties
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| Description | Anti-Phospho-Shc (Tyr349) Polyclonal Antibody is a Rabbit antibody targeting Phospho-Shc (Tyr349). Anti-Phospho-Shc (Tyr349) Polyclonal Antibody can be used in IF,WB. |
| Synonyms | Shc (p-Y349), Shc (p-Tyr349), p-Shc (Y349), p-Shc (Tyr349) |
| Ig Type | IgG |
| Reactivity | Human,Mouse |
| Verified Activity | 1. Western blot analysis of extracts from HepG2 cells untreated or treated with EGF using Shc1 (Phospho-Tyr349) Antibody TMAC-03737. 2. Immunofluorescence staining of methanol-fixed Hela cells using Shc1 (Phospho-Tyr349) Antibody TMAC-03737.   |
| Application | |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Construction | Polyclonal Antibody |
| Purification | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. |
| Appearance | Liquid |
| Formulation | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Research Background | Signaling adapter that couples activated growth factor receptors to signaling pathway. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span |
| Conjucates | Unconjugated |
| Others Formats | Phospho |
| Immunogen | Peptide sequence around phosphorylation site of tyrosine 349 (H-Q-Y(p)-Y-N) derived from Human Shc1 |
| Antigen Species | human |
| Uniprot ID |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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