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PF-4800567

Name: PF-4800567
Brand: TargetMol
SKU: T5056
Price: 38 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5056Cas No. 1188296-52-7

PF-4800567 is a selective inhibitor of casein kinase 1ε (CK1ε; IC50 = 32 nM) with greater than 20-fold selectivity over CK1δ.

PF-4800567

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Purity: 99.76%

Catalog No. T5056Cas No. 1188296-52-7

PF-4800567 is a selective inhibitor of casein kinase 1ε (CK1ε; IC50 = 32 nM) with greater than 20-fold selectivity over CK1δ.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$38	In Stock	In Stock
10 mg	$58	In Stock	In Stock
25 mg	$137	In Stock	In Stock
50 mg	$206	In Stock	In Stock
100 mg	$298	In Stock	In Stock
200 mg	$433	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$42	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.76%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS HPLC

Product Introduction

Bioactivity

Description	PF-4800567 is a selective inhibitor of casein kinase 1ε (CK1ε; IC50 = 32 nM) with greater than 20-fold selectivity over CK1δ.
Targets&IC50	CKIδ:711 nM, CK1ε:32 nM
In vitro	PF-4800567 shows inhibitory activity against CK1ε and CK1δ in whole cells, with IC50s of 2.65 and 20.38 μM, respectively. PF-4800567 (0.01-10 μM) blocks CK1?-mediated PER3 nuclear localization mediated by CK1? and suppresses PER2 degradation at 1 μM. In addition, PF-4800567 (32 nM) has little effect on the circadian clock [1].
In vivo	PF-4800567 (100 mg/kg, s.c.) is quickly absorbed and distributed in the plasma and brain of mice [1].

Chemical Properties

Molecular Weight	359.81
Formula	C₁₇H₁₈ClN₅O₂
Cas No.	1188296-52-7
Smiles	Nc1ncnc2n(nc(COc3cccc(Cl)c3)c12)C1CCOCC1
Relative Density.	1.52 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from direct sunlight,store under nitrogen,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (166.75 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.56 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7792 mL	13.8962 mL	27.7924 mL	138.9622 mL
5 mM	0.5558 mL	2.7792 mL	5.5585 mL	27.7924 mL
10 mM	0.2779 mL	1.3896 mL	2.7792 mL	13.8962 mL
20 mM	0.1390 mL	0.6948 mL	1.3896 mL	6.9481 mL
50 mM	0.0556 mL	0.2779 mL	0.5558 mL	2.7792 mL
100 mM	0.0278 mL	0.1390 mL	0.2779 mL	1.3896 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc