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Enalaprilat

Name: Enalaprilat
Brand: TargetMol
SKU: T6340L
Rating: 4.5 (1 reviews)

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Catalog No. T6340LCas No. 76420-72-9

Alias MK-422, MK422, MK 421 diacid, Enalapril acid

Enalaprilat (Enalapril acid) is a potent angiotensin-converting enzyme (ACE) inhibitor that enhances arterial and cardiopulmonary pressure reflex control of sympathetic activity in patients with heart failure, and can be used in the study of cardiovascular disease.

Enalaprilat

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Catalog No. T6340LAlias MK-422, MK422, MK 421 diacid, Enalapril acidCas No. 76420-72-9

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
25 mg	$29	7-10 days	7-10 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Appearance:Solid

Color:White

Resource Download

COA HPLC MS HNMR

Product Introduction

Bioactivity

Description	Enalaprilat (Enalapril acid) is a potent angiotensin-converting enzyme (ACE) inhibitor that enhances arterial and cardiopulmonary pressure reflex control of sympathetic activity in patients with heart failure, and can be used in the study of cardiovascular disease.
Targets&IC50	ACE:1.94 nM, IGF-I-induced proliferation of neonatal cardiac fibroblasts (rat):90 nM
In vitro	Enalaprilat, the active metabolite of the orally administered drug enalapril, exhibits potent, competitive and long-lasting angiotensin-converting enzyme (ACE) inhibition with an IC50 of 1.94 nM.[1] Enalaprilat (1 nM-10 μM; 24 hours) inhibited IGF-I-induced proliferation of neonatal rat cardiac fibroblasts by 30% in a concentration-dependent manner with an IC50 of 90 nM.[2]
In vivo	Enalaprilat (0.01%-2.9% ophthalmic concentration) showed significant IOP-lowering effect in rabbit IOP assay. [3]
Synonyms	MK-422, MK422, MK 421 diacid, Enalapril acid

Chemical Properties

Molecular Weight	348.39
Formula	C₁₈H₂₄N₂O₅
Cas No.	76420-72-9
Smiles	C([C@@H](N[C@@H](CCC1=CC=CC=C1)C(O)=O)C)(=O)N2[C@H](C(O)=O)CCC2
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (229.63 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8703 mL	14.3517 mL	28.7035 mL	143.5173 mL
5 mM	0.5741 mL	2.8703 mL	5.7407 mL	28.7035 mL
10 mM	0.2870 mL	1.4352 mL	2.8703 mL	14.3517 mL
20 mM	0.1435 mL	0.7176 mL	1.4352 mL	7.1759 mL
50 mM	0.0574 mL	0.2870 mL	0.5741 mL	2.8703 mL
100 mM	0.0287 mL	0.1435 mL	0.2870 mL	1.4352 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc