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Izalontamab
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Catalog No. T77047Cas No. 2559704-24-2
Alias SI-B001, SIB001
Izalontamab (SI-B001) is a bispecific EGFR/HER3 monoclonal antibody that binds to both EGFR×EGFR homodimers and EGFR×HER3 heterodimers, thereby blocking downstream pathways. It is applicable for locally advanced or metastatic epithelial tumours, such as non-small cell lung cancer (NSCLC) and head and neck squamous cell carcinoma (HNSCC).
Izalontamab
Izalontamab
😃Good
Catalog No. T77047Alias SI-B001, SIB001Cas No. 2559704-24-2
Izalontamab (SI-B001) is a bispecific EGFR/HER3 monoclonal antibody that binds to both EGFR×EGFR homodimers and EGFR×HER3 heterodimers, thereby blocking downstream pathways. It is applicable for locally advanced or metastatic epithelial tumours, such as non-small cell lung cancer (NSCLC) and head and neck squamous cell carcinoma (HNSCC).
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $538 | - | In Stock | |
| 5 mg | $1,380 | - | In Stock | |
| 10 mg | $2,230 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:95.3% (SDS-PAGE); 99.2% (SEC-HPLC)
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| Description | Izalontamab (SI-B001) is a bispecific EGFR/HER3 monoclonal antibody that binds to both EGFR×EGFR homodimers and EGFR×HER3 heterodimers, thereby blocking downstream pathways. It is applicable for locally advanced or metastatic epithelial tumours, such as non-small cell lung cancer (NSCLC) and head and neck squamous cell carcinoma (HNSCC). |
| In vivo | Izalontamab (5-46 mg/kg, intravenous injection, once every 7 days for a total of 4 doses) demonstrated significant antitumor efficacy in female NOD/SCID mice bearing SW48, FaDu, and KYSE-150 parazacco spilurus subsp. spilurus xenograft tumors. [1] |
| Synonyms | SI-B001, SIB001 |
| Reactivity | Human |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | EGFR & ERBB3 |
| Molecular Weight | 197.21 kDa |
| Cas No. | 2559704-24-2 |
| Color | Transparent |
| Appearance | Liquid |
| Isotype | Human IgG1 kappa |
| Recommended Isotype Control |
| Storage | store at low temperature | store at -20°C | Shipping with blue ice/Shipping at ambient temperature. |
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