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Antibacterial agent 292
Catalog No. T213322 Copy Product Info
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Antibacterialagent 292 is a derivative of 3-pyrazolylindole and functions as an antibacterial agent. It exhibits potent inhibitory activity against Xanthomonas oryzae pv oryzae (Xoo) and Xanthomonas axonopodis pv citri (Xac), with EC50 values of 2.54 μg/mL and 3.49 μg/mL, respectively. It inhibits biofilm formation, bacterial motility, and extracellular polysaccharide production, induces morphological changes, promotes reactive oxygen species (ROS) accumulation, and leads to bacterial apoptosis. Additionally, it downregulates gene expression related to the type VI secretion system (T6SS). Antibacterialagent 292 can be applied in the management of bacterial leaf blight in rice and citrus canker.
Antibacterial agent 292
Copy Product Info🥰Excellent
Catalog No. T213322
Antibacterialagent 292 is a derivative of 3-pyrazolylindole and functions as an antibacterial agent. It exhibits potent inhibitory activity against Xanthomonas oryzae pv oryzae (Xoo) and Xanthomonas axonopodis pv citri (Xac), with EC50 values of 2.54 μg/mL and 3.49 μg/mL, respectively. It inhibits biofilm formation, bacterial motility, and extracellular polysaccharide production, induces morphological changes, promotes reactive oxygen species (ROS) accumulation, and leads to bacterial apoptosis. Additionally, it downregulates gene expression related to the type VI secretion system (T6SS). Antibacterialagent 292 can be applied in the management of bacterial leaf blight in rice and citrus canker.
Antibacterial agent 292
Cas No. 3065015-86-0
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.
For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Antibacterialagent 292 is a derivative of 3-pyrazolylindole and functions as an antibacterial agent. It exhibits potent inhibitory activity against Xanthomonas oryzae pv oryzae (Xoo) and Xanthomonas axonopodis pv citri (Xac), with EC50 values of 2.54 μg/mL and 3.49 μg/mL, respectively. It inhibits biofilm formation, bacterial motility, and extracellular polysaccharide production, induces morphological changes, promotes reactive oxygen species (ROS) accumulation, and leads to bacterial apoptosis. Additionally, it downregulates gene expression related to the type VI secretion system (T6SS). Antibacterialagent 292 can be applied in the management of bacterial leaf blight in rice and citrus canker. |
| In vitro | Antibacterial agent 292 (Compound P16) effectively inhibits the growth of Xoo and Xac cells at concentrations ranging from 3.125 to 25 μg/mL. At concentrations between 3.125 and 12.5 μg/mL, it increases the accumulation of reactive oxygen species and induces apoptosis in these cells. Furthermore, the agent, at concentrations of 3.125 to 50 μg/mL, hinders biofilm formation, extracellular polysaccharide content, and motility of Xoo and Xac cells. Additionally, Antibacterial agent 292 reduces the expression of vgrG, hcp, and clpV in the Type VI secretion system (T6SS) of Xoo cells. |
| Molecular Weight | 448.96 |
| Formula | C24H25ClN6O |
| Cas No. | 3065015-86-0 |
| Smiles | O=C(NC1=CC(=NN1)C2=CNC=3C=CC=CC32)CN4CCN(CC5=CC=C(Cl)C=C5)CC4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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